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A 37-year-old male with severe skin and internal issues has a rare inherited skin condition called dystrophic epidermolysis bullosa.

The study created hair-bearing skin models that lack a key protein for skin layer attachment, limiting their use for certain skin disease research.

Tumor cell adhesion is linked to higher risk of SLN metastasis and melanoma recurrence, and a model including these factors predicts these outcomes better than one with just clinical data.

Muscle around hair follicles controls hair loss by releasing a signal that causes cell death.

The document concludes that stem cells and their environments are crucial for skin and hair health and have potential for medical treatments.

Stem cells compete for space using cell adhesion, and mutations can affect their competitive success, with implications for tissue health and disease.

α3β1-integrin is crucial for maintaining normal hair follicle shape and function but not needed for the development of the surrounding skin.

Ectomesenchyme is a key source of skin stem cells.

Notch signalling helps skin cells differentiate and prevents tumors.

Removing integrin α3β1 from hair stem cells lowers skin tumor growth by affecting CCN2 protein levels.

ILK is essential for proper hair follicle development and structure.

Cells that move well may improve hair loss treatments by entering hair follicles.

A special mix from certain skin cells can help hair grow by making hair root cells grow faster and activating growth signals.

Certain human skin cells marked by CD44 and ALDH are rich in stem cells capable of long-term skin renewal.

Kaempferol helps skin stem cells grow and may improve skin thickness due to its 3-OH group.

The protein aPKCλ is crucial for keeping hair follicle stem cells inactive and for hair growth and regeneration.

The research found a way to identify and study skin cells with stem cell traits, revealing they behave differently in culture and questioning current stemness assessment methods.

ILK and ELMO2 help cells move and stick together, important for wound healing and hair growth.

Scientists used stem cells to create a model of the skin disease Epidermolysis Bullosa simplex, which helped them understand its molecular mechanisms and could aid in finding treatments.

Epidermal stem cells use integrin β1 and α6 as markers and CD271+ cells help maintain skin health and heal wounds.

Removing a methyl group from the ITGAV gene speeds up bone formation in a specific type of bone disease model.

Biologic treatments for Crohn's disease and ulcerative colitis can cause skin problems, and doctors should adjust treatment if these occur.

New therapies are being developed that target integrin pathways to treat various diseases.

Mongolian gerbils heal wounds differently than mice, with unique protein levels and gene expression that affect skin repair.

CD98hc's role in skin health decreases with age.

Hair follicle cells resist turning into skin cells.

Alopecia areata patients show unique protein activity patterns, suggesting imbalanced signaling pathways.

Researchers found a new mutation in the FERMT1 gene in a Spanish family with Kindler syndrome.

Scarred skin in lichen planopilaris loses immune cells due to a decrease in a specific protein in skin cells.

Integrin alphavbeta6 is important for wound healing and hair growth, and blocking it may improve these processes.