19 citations
,
March 2010 in “Bioorganic & Medicinal Chemistry Letters” This study evaluated curcumin analogues as potential inhibitors of 17β-HSD3 in rat and human models, but it does not report new clinical findings.
18 citations
,
October 2020 in “Journal of Pharmacology and Experimental Therapeutics” In isolated rat lymph vessels, this study found that ATP-sensitive potassium channel openers impair lymph contractions and reduce lymph flow, potentially contributing to peripheral edema.
November 2022 in “Journal of Investigative Dermatology” This study found that marine-derived collagen peptides slightly promoted hair matrix proliferation and prolonged hair growth phase in human hair follicles ex vivo, suggesting potential benefits for hair loss treatment.
This study suggests that bovine and fish-derived collagen peptides may help maintain or prolong the hair growth phase and balance hair follicle stem cell populations, potentially benefiting aging and hair loss conditions like androgenetic alopecia.
44 citations
,
February 2009 in “Pain” This study found that progesterone can inhibit spinal reflex potentiation in ovariectomized rats through GABA(A) receptor activity, mediated by neurosteroid metabolism rather than direct progesterone receptor action.
4 citations
,
April 2019 in “Cell Stem Cell” This study found that a specific macrophage subpopulation in the dermis helps maintain hair follicle stem cell quiescence through cytokine-mediated signaling.
December 2024 in “Journal of Biophotonics” In this study, researchers observed that red and red-orange LED light therapy stimulates nitric oxide production and decreases dihydrotestosterone synthesis in cell models, suggesting a potential mechanism for using light therapy to treat androgenetic alopecia.
3 citations
,
November 2021 in “IntechOpen eBooks” This chapter reviews the role of the testes in producing and functioning of testicular androgens and protein hormones, but it presents no new clinical results.
7 citations
,
May 2022 in “PLOS ONE” This study found that Hetian sheep with higher wool density produce more and finer wool, with key genes potentially influencing their wool growth and density.
July 2021 in “Advances in laboratory medicine” This article reviews differential diagnosis approaches for 46,XY DSD, proposing a diagnostic algorithm focused on biochemical and genetic data, without presenting new clinical results.
May 2021 in “Journal of the Endocrine Society” This case report describes a 47-year-old woman diagnosed with a rare Sertoliform endometrioid carcinoma of the ovary, emphasizing its early-stage presentation and generally favorable prognosis.
3 citations
,
April 2021 in “Journal of Medicinal Chemistry” This study suggests that finasteride may inhibit the enzyme PNMT, potentially contributing to its sexual and psychological side effects.
34 citations
,
May 1987 in “European Journal of Pediatrics” This study concluded that Buserelin can effectively inhibit gonadal activity in children with central precocious puberty over 18 months, potentially improving final height predictions with prolonged treatment.
36 citations
,
January 2018 in “Burns & Trauma” This review suggests that while NSAIDs may inhibit bone healing and have variable effects on other complications, caution is advised in their prescription post-surgery, particularly for female patients.
6 citations
,
February 2021 in “Frontiers in Cell and Developmental Biology” This study suggests that vitamin A may inhibit hair follicle stem cells during refractory telogen in a dose-dependent manner, based on retinyl ester levels and vitamin A metabolism protein localization in mice.
95 citations
,
January 2012 in “British Journal of Dermatology” This study found that androgens inhibit hair follicle stem cell differentiation by disrupting the Wnt signalling pathway in dermal papilla cells, but Wnt activation can restore differentiation.
56 citations
,
December 1990 in “Differentiation” Growth factors can either promote or inhibit hair follicle cell growth and collagen breakdown.
17 citations
,
December 2015 in “Bioorganic & Medicinal Chemistry” 3-tetrazolo steroidal analogs can strongly inhibit the enzyme linked to hair loss.
13 citations
,
December 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” This study observed that nicotinamide can effectively inhibit human hair growth and promote hair follicle regression in cultured human scalp models without negatively affecting epidermal vitality, suggesting its potential as a hair growth inhibitor in cosmetic applications.
6 citations
,
October 2018 in “PLoS ONE” This study found that chronic stress may inhibit hair follicle growth and melanogenesis in mice through modulation of the central HPA axis, with C57BL/6 mice appearing most sensitive to these effects.
2 citations
,
January 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that androgen signaling can inhibit Wnt-stimulated growth in prostate basal cell organoids, suggesting a key role in regulating their multipotency.
April 2011 in “ChemInform” A new compound may effectively inhibit the enzyme linked to BPH and hair loss.
January 2008 in “Journal of Medicinal Chemistry” This study suggests that finasteride may inhibit the enzyme phenylethanolamine N-methyltransferase, which could contribute to its sexual and psychological side effects.
August 2026 in “ACS Applied Bio Materials” This study found that exosome-like nanoparticles derived from leeks promoted hair follicle stem cell proliferation and migration, enhanced antioxidant capacities, reduced inflammation, and inhibited hair maturation in rats by altering differentiation pathways, suggesting potential therapeutic benefits for managing hirsutism.
May 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” This study found that tofacitinib may inhibit CD8+ T cell infiltration in alopecia areata by affecting the linoleic acid metabolism-Mg2+ pathway in a sodium sulfide-induced mouse model, highlighting new insights for clinical diagnosis and treatment strategies.
May 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” This study revealed that tofacitinib may inhibit CD8+ T cell infiltration in alopecia areata by modulating the linoleic acid metabolism-Mg2+ pathway, providing new insights for potential treatments and diagnosis.
September 2018 in “Chinese Journal of Dermatology” This study found that angiogenin can inhibit the expression of type Ⅰ collagen and fibronectin in dermal papilla cells from androgenetic alopecia areas in vitro by affecting TGF-β1 and its signaling pathway.
47 citations
,
August 2016 in “Fitoterapia” This article reviews mechanisms by which herbal ingredients may stimulate or inhibit hair growth, and it reports no new clinical findings while suggesting potential for developing hair loss treatments.
16 citations
,
March 2017 in “Oncotarget” This study suggests that SOCS3 treatment may effectively inhibit alopecia areata by suppressing CD8+ T cell activity and IFN-γ production.
11 citations
,
March 2019 in “Journal of Medicinal Chemistry” This study reports that synthetic carbohydrate receptors effectively inhibit Zika virus infection in cell cultures by blocking early stages of viral entry.