Marine and Bovine-Derived Collagen Peptides Inhibit Catagen Development and Affect Stem Cells in Human Scalp Hair Follicles
December 2022
in “
Journal of Investigative Dermatology
”
collagen peptides bovine-derived collagen peptides fish-derived collagen peptides Peptan®B Peptan®Marine hair follicle biology hair matrix keratinocyte proliferation anagen phase K15+ hair follicle stem cells K19+ hair follicle stem cells CD34+ cells apoptosis androgenetic alopecia bovine collagen peptides fish collagen peptides hair growth phase hair stem cells hair loss
TLDR Fish-derived collagen may help hair grow longer and affect hair stem cells, while bovine collagen could benefit hair stem cell maintenance, potentially aiding in hair loss conditions.
The study investigated the effects of bovine (Peptan®B) and fish (Peptan®Marine)-derived collagen peptides on hair follicle biology. Human hair follicles were treated ex vivo with these collagen peptides. The results showed that Peptan®Marine slightly increased hair matrix keratinocyte proliferation and significantly prolonged anagen, the active growth phase of hair follicles. It did not alter the numbers of K15+ or K19+ hair follicle stem cells (HFSCs), but significantly reduced the proliferation of K15+ cells and increased the number of CD34+ cells. On the other hand, Peptan®B did not affect the hair cycle or numbers of CD34+ cells, but significantly increased K15+ cells and reduced their proliferation. It also inhibited apoptosis in K15+ cells and increased K19+ cells. The study suggests that collagen peptides maintain or prolong anagen and balance HFSCs and their progeny, indicating potential benefits of collagen peptide supplementation for aging and hair loss disorders, such as androgenetic alopecia.
