TLDR 3-tetrazolo steroidal analogs can strongly inhibit the enzyme linked to hair loss.
The study focused on synthesizing and evaluating 3-tetrazolo steroidal analogs as a novel class of 5α-reductase inhibitors. These compounds were tested for their ability to inhibit human 5α-reductase, an enzyme involved in the conversion of testosterone to dihydrotestosterone, which is linked to conditions like hair loss. The analogs demonstrated varying levels of inhibitory activity, with IC50 values ranging from 40 nM to 547 nM. The most potent compound, BDBM50334788, showed an IC50 of 40 nM, indicating strong inhibition of the enzyme. The research provided insights into the potential of these analogs as therapeutic agents for conditions related to 5α-reductase activity.
17 citations
,
June 2012 in “European journal of medicinal chemistry” New steroid compounds effectively inhibit 5α-reductase and may treat hair loss.
136 citations
,
March 1996 in “Journal of the American Chemical Society” Finasteride effectively blocks enzyme causing male pattern baldness.
May 2022 in “Current Enzyme Inhibition” Compound 7b is a promising candidate for treating benign prostatic hyperplasia and prostate cancer.
7 citations
,
February 2020 in “Analytical and Bioanalytical Chemistry” 
51 citations
,
May 2013 in “The Journal of Steroid Biochemistry and Molecular Biology” Certain drugs that block specific enzymes can help treat prostate diseases.
20 citations
,
June 2022 in “Molecules” Thiazole, a sulfur and nitrogen chemical, is useful in creating potential drugs for conditions like seizures, cancer, bacterial infections, tuberculosis, inflammation, malaria, viruses, Alzheimer's, diabetes, and A1-receptor issues.
70 citations
,
September 2017 in “Expert opinion on therapeutic patents” The review suggests that while many AKR1C3 inhibitors show promise for treating certain cancers, more research is needed to confirm their effectiveness in humans.
