Marine and Bovine-Derived Collagen Peptides Inhibit Catagen Development and Affect Stem Cells in Human Scalp Hair Follicles
September 2022
TLDR Collagen peptides may help maintain hair growth and could be beneficial for hair loss conditions.
The study investigated the effects of bovine (Peptan®B) and fish (Peptan®Marine)-derived collagen peptides on human hair follicle biology. The research used human microdissected male and female hair follicles treated ex vivo with in vitro-digested collagen peptides. The results showed that Peptan®Marine slightly increased hair matrix keratinocyte proliferation and significantly prolonged anagen ex vivo, while not altering the numbers of K15+ or K19+ hair follicle stem cells (HFSCs). On the other hand, Peptan®B significantly increased K15+ cells in the bulge, inhibited apoptosis in K15+ cells, and increased K19+ cells. The study concluded that collagen peptides maintain or prolong anagen and balance HFSC (K15+) and their progeny (CD34+ and K19+), suggesting that nutraceutical supplementation with collagen peptides could be beneficial for aging and hair loss disorders, such as androgenetic alopecia.
