Associations Between Ionomic Profile and Metabolic Abnormalities in a Murine Model of Sodium Sulfide-Induced Alopecia Areata

    May 2025 in “ OPAL (Open@LaTrobe) (La Trobe University) ”
    Luning Li (8908169), Zhen Sun (269397), Wenxue Sun (6489719), Yujuan Zhai (410582), Na Ding (642632), Wei Wang (17594)
    TLDR Linoleic acid and magnesium are key in alopecia areata progression, and tofacitinib can help by affecting their pathway.
    This study investigated the metabolic and ionic changes in a murine model of sodium sulfide-induced alopecia areata (AA) using 36 Kunming mice divided into control, AA model, and tofacitinib-treated groups. Metabolomics and ionomics analyses identified key metabolites such as D-lactic acid and linoleic acid, and ions like magnesium and nickel, which are involved in AA's pathogenesis. The study found that linoleic acid metabolism and magnesium play crucial roles in modulating CD8<sup>+</sup> T cell infiltration, influencing AA progression. Tofacitinib treatment was shown to inhibit this infiltration by affecting the linoleic acid metabolism-Mg<sup>2+</sup> pathway, offering new insights for AA diagnosis and treatment.
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