Associations Between Ionomic Profile and Metabolic Abnormalities in a Murine Model of Sodium Sulfide-Induced Alopecia Areata
May 2025
in “
OPAL (Open@LaTrobe) (La Trobe University)
”
Studysummary This study revealed that tofacitinib may inhibit CD8<sup>+</sup> T cell infiltration in alopecia areata by modulating the linoleic acid metabolism-Mg<sup>2+</sup> pathway, providing new insights for potential treatments and diagnosis.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
This study investigated the metabolic and ionic changes in a murine model of sodium sulfide-induced alopecia areata (AA) using 36 Kunming mice divided into control, AA model, and tofacitinib-treated groups. Metabolomics and ionomics analyses identified key metabolites such as D-lactic acid and linoleic acid, and ions like magnesium and nickel, which are involved in AA's pathogenesis. The study found that linoleic acid metabolism and magnesium play crucial roles in modulating CD8<sup>+</sup> T cell infiltration, influencing AA progression. Tofacitinib treatment was shown to inhibit this infiltration by affecting the linoleic acid metabolism-Mg<sup>2+</sup> pathway, offering new insights for AA diagnosis and treatment.
