Associations Between Ionomic Profile and Metabolic Abnormalities in a Murine Model of Sodium Sulfide-Induced Alopecia Areata

    May 2025 in “ OPAL (Open@LaTrobe) (La Trobe University) ”
    Luning Li (8908169), Zhen Sun (269397), Wenxue Sun (6489719), Yujuan Zhai (410582), Na Ding (642632), Wei Wang (17594)
    TLDR Targeting specific metabolic and ionic pathways may improve alopecia areata treatment.
    This study investigated the metabolic and ionic changes in a murine model of sodium sulfide-induced alopecia areata (AA) using 36 Kunming mice divided into control, AA model, and tofacitinib-treated groups. Metabolomics and ionomics analyses identified key metabolites such as D-lactic acid and linoleic acid, and ions like magnesium and nickel, which are involved in AA's pathogenesis. The study found that tofacitinib treatment modulates the linoleic acid metabolism-Mg²⁺ pathway, inhibiting CD8⁺ T cell infiltration in hair follicles, thus influencing AA progression. These findings suggest that targeting these pathways could improve AA treatment outcomes.
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