Vinegar-Processed Black Soybean Promotes Hair Growth And Prevents Alopecia Via Wnt/β-Catenin Pathway

    July 2025 in “ PubMed ”
    Yue Zhang, Miaomiao Wu, Jiasen Li, Chenghao Zhao, Tingyuan Zhou, Huiling Wei, Jiaxin He, Yao Yao, Juan Li
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    TLDR Vinegar-processed black soybean helps hair growth and prevents hair loss.
    This study explored the effects of vinegar-processed black soybean (VPBS) and its aqueous extract (VPBS-AE) on hair growth and alopecia prevention in C57BL/6J mice. Mice treated with VPBS or VPBS-AE showed accelerated hair growth, stimulated anagen phase entry, and reduced cyclophosphamide-induced alopecia. The treatments promoted follicular repair and preserved follicle integrity. Mechanistically, VPBS-AE restored Wnt10b/β-catenin expression and suppressed GSK-3β, suggesting that its therapeutic effects are mediated through the Wnt/β-catenin pathway. These findings support VPBS and VPBS-AE as potential functional foods for hair regeneration and alopecia prevention.
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