Associations Between Ionomic Profile and Metabolic Abnormalities in a Murine Model of Sodium Sulfide-Induced Alopecia Areata

This study investigated the metabolic and ionic changes in a murine model of sodium sulfide-induced alopecia areata (AA) using 36 Kunming mice divided into control, AA model, and tofacitinib-treated groups. Metabolomics and ionomics analyses identified key metabolites such as D-lactic acid and linoleic acid, and ions like magnesium and nickel, which are involved in AA's pathogenesis. The study found that tofacitinib treatment modulates the linoleic acid metabolism-Mg²⁺ pathway, inhibiting CD8⁺ T cell infiltration in hair follicles, thus influencing AA progression. These findings suggest that targeting these pathways could improve AA diagnosis and treatment.