Modulation of the Canonical Wnt Activity by Androgen Signaling in Prostate Epithelial Basal Stem Cells

January 2020 in “ bioRxiv (Cold Spring Harbor Laboratory) ”

Yueli Liu, Jiawen Wang, Corrigan Horton, Sol Katzman, Tao Cai, Zhu A. Wang

Wnt signaling androgen signaling dihydrotestosterone DHT androgen receptor AR β-catenin

TLDR Androgen signaling reduces Wnt activity, affecting prostate stem cell growth.

The study investigated the interaction between canonical Wnt signaling and androgen signaling in prostate epithelial basal stem cells. It was found that while Wnt activity was necessary for the multipotency of these stem cells, it did not promote their differentiation into luminal cells. Androgen signaling, particularly through dihydrotestosterone (DHT), was shown to antagonize Wnt-stimulated growth in organoid cultures, suggesting that androgen signaling could regulate Wnt activity. Molecular analyses indicated that androgen signaling down-regulated Wnt target genes and enhanced the binding of androgen receptors and β-catenin in the nuclei, highlighting a critical role of androgen receptor signaling in modulating Wnt activity to regulate stem cell multipotency.

View this study on biorxiv.org →

Discuss this study in the Community →

Related Community Posts Join

6 / 95 results

community 30-Min Dermatology Visit – Best Questions to Ask About Balding? ( 175$ )

in Treatment 6 upvotes 7 months ago

The conversation discusses hair loss treatments, focusing on finasteride, minoxidil, and other options like PRP and ketoconazole. It highlights the importance of asking specific questions during a dermatology visit to determine the cause of hair loss and appropriate treatments.

community NMN Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

in Research/Science 14 upvotes 1 year ago

NMN shows promise in promoting hair growth by reducing oxidative stress and weakening androgens. It may be a beneficial addition to hair loss treatments like Minoxidil and Finasteride.

community DIY treatment... Shedding completely stopped after 1.5 yrs

in Treatment 249 upvotes 3 years ago

Vitamin C mixed with shampoo stopped shedding and promoted hair regrowth after 1.5 years. Both the person and their wife experienced significant hair loss reduction with this method.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 672 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 11 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Better Than Minoxidil? Topical Sodium Valproate

in Research/Science 50 upvotes 8 months ago

Topical sodium valproate may promote hair growth by inhibiting GSK3β, allowing beta-catenin to proliferate, but it has potential side effects and requires more research. The conversation also mentions skepticism about a product called Vdphlo1, which includes sodium valproate and other ingredients.