This study found that lupus discoid lesions on the scalp are more common in females and are associated with a higher incidence of other autoimmune diseases compared to lesions in other areas.
56 citations
,
January 2021 in “Clinical and Experimental Medicine” This review highlights the challenges in treating alopecia areata, noting that current therapies often lead to relapse and have uncertain long-term effectiveness; it also points to potential future treatments such as JAK-STAT inhibitors and PRP.
22 citations
,
March 1994 in “Journal of Heredity” In this study, researchers identified a mutation in mice that causes hair loss and immune system issues, located on chromosome 18.
January 2024 in “Wiadomości Lekarskie” This preclinical study found that exercise-induced extracellular vesicles delayed breast cancer tumor growth in mice, potentially by enhancing the immune response within the tumor microenvironment.
August 2023 in “Medical Hypotheses” In this review, researchers discussed the anti-inflammatory and immunomodulatory properties of metformin and hypothesized that its topical application could benefit those with alopecia areata, given its effects on immune pathways, hair regrowth, and autoimmune disease management.
May 1988 in “Journal of Forensic Sciences” This study reports an improved method for determining blood type from human hair using immunohistochemistry.
January 2026 in “International Journal of Research and Innovation in Applied Science” In this case report, a 45-year-old woman with systemic lupus erythematosus underwent a six-month integrative naturopathic and yoga program while continuing conventional treatment, aiming to document improvements in disease management and patient well-being.
7 citations
,
October 2013 in “Methods in molecular biology” This article describes standard methods for studying DNA methylation dynamics in mouse skin and hair follicle stem cells but presents no new research findings.
3 citations
,
August 2012 in “Annals of Diagnostic Pathology” This study found that women with AIDS had significantly reduced epithelial thickness and more telogen hair follicles on the scalp compared to women without AIDS.
September 2024 in “Journal of the American Academy of Dermatology” Organizations help patients access discounts for expensive dermatology medications.
278 citations
,
May 2013 in “Ca” This review discusses the shift in toxicity profiles of cancer therapies from traditional chemotherapy to targeted agents, noting similar overall toxicities but with different side effects, and reports no new findings.
156 citations
,
August 2016 in “Journal of controlled release” This review summarizes current knowledge on tight junctions in mammalian skin and their role in drug delivery and interaction with other barrier components, but reports no new experimental results.
138 citations
,
November 1974 in “Biological reviews/Biological reviews of the Cambridge Philosophical Society” This review explores the structural and functional sex differences in mammals beyond reproductive organs, highlighting variations in life expectancy, organ size, metabolism, and immune function, but it reports no new results.
87 citations
,
February 2009 in “PubMed” This review discusses the potential causes and treatments for alopecia in nonhuman primates, emphasizing the need for comprehensive testing before attributing hair loss to stress.
53 citations
,
June 2020 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” This review discusses the development and use of various animal models for studying psoriasis, highlighting their strengths and limitations, but reports no new experimental results.
50 citations
,
March 2000 in “American Journal of Clinical Dermatology” This article discusses the etiology, clinical features, and treatment of alopecia areata but presents no new clinical findings, underlining the palliative nature of current therapies.
49 citations
,
August 2007 in “Dermatologic surgery” This review discusses newer therapeutic techniques for treating postacne scarring, highlighting their effectiveness for particular grades of scars, and reports no new clinical results.
46 citations
,
September 2010 in “Veterinary Dermatology” This retrospective study documented various skin diseases in alpacas, reporting bacterial infections as the most common, along with other conditions described for the first time.
45 citations
,
May 2024 in “International Journal of Molecular Sciences” This manuscript reviews the latest understanding of alopecia areata's pathogenesis, highlighting the roles of genetic, immunological, and environmental factors, with a focus on immune responses involving IFN-γ and cytotoxic CD8+ T-cells as key contributors to hair follicle inflammation and function disruption without follicle destruction.
31 citations
,
January 2016 in “Skin Appendage Disorders” This study observed two cases of frontal fibrosing alopecia developing on preexisting vitiligo, suggesting a potential causal link between the two conditions.
29 citations
,
April 2000 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry” This study found that ICAM-1 expression in murine skin is developmentally regulated and crucial for skin and hair follicle remodeling beyond its recognized role in immune responses.
27 citations
,
December 2015 in “Mayo Clinic Proceedings” This review presents an evidence-based algorithm for managing hidradenitis suppurativa in primary care, highlighting the need for more research on treatment effectiveness and the disease's pathogenesis.
26 citations
,
June 2012 in “The Journal of Obstetrics and Gynecology of India” This review discusses various skin changes during pregnancy, noting that while most are benign and resolve after childbirth, some may require careful medical management for the safety of the mother and fetus; it reports no new results.
23 citations
,
November 2014 in “Anais Brasileiros de Dermatologia” This study suggests that trichoscopy may assist in diagnosing pemphigus, particularly for scalp-specific lesions, by identifying certain characteristic features.
17 citations
,
June 2017 in “Gene” This is the first report of the FOXN1 p.R255X mutation from India, demonstrating the global spread of this genetic mutation previously found only in an Italian community.
15 citations
,
January 2018 in “Acta dermato-venereologica” This study found that dermatological treatments significantly reduce health-related quality of life among patients with various skin conditions, suggesting that the burden of these therapies should be considered in treatment planning and development.
12 citations
,
April 2022 in “Dermatology and therapy” This study reports that patients with alopecia areata in the US incur significantly higher healthcare utilization and expenses, primarily driven by ambulatory and pharmacy costs, compared to matched controls.
12 citations
,
January 2000 in “Journal of cutaneous medicine and surgery” This case study suggests that overgrowth of microorganisms with hyperkeratosis may contribute to the induction of lichen planopilaris by disrupting the immune privilege of hair follicles.
11 citations
,
October 2021 in “Orphanet journal of rare diseases” This study found that patients with RASopathies have lower serum IgA and CD8 levels compared to controls, indicating a potential risk for developing autoimmune disorders.
9 citations
,
January 2023 in “Journal of the European Academy of Dermatology and Venereology” This study suggests that genetic overlap between alopecia areata and major depressive disorder may be limited to the MHC region, highlighting the need for further research.