Exercise-Induced Extracellular Vesicles Delay Tumor Development Via Igniting the Inflammation in the Immunologically Cold Breast Cancer Model

This preclinical study investigated the effects of exercise-induced extracellular vesicles (EVs) on breast cancer progression using two mouse models. Mice subjected to a treadmill exercise regimen showed increased plasma EVs levels. Treatment with these EVs led to a significant delay in tumor growth by approximately 30% compared to controls. The study found that EVs had immunomodulatory effects on the tumor microenvironment, particularly through the influx of cytotoxic CD8+ T cells. These findings suggest that exercise-induced EVs could serve as a potential immunomodulatory treatment to enhance inflammation in the tumor bed, highlighting the therapeutic role of physical activity in breast cancer.