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The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Stem cell niches are crucial for regulating stem cell behavior and tissue health, and their decline can impact aging and cancer.

Treatments that reduce oxidative stress and fix mitochondrial problems may help heal chronic wounds.

Epithelial-mesenchymal interactions control hair growth cycles through specific molecular signals.

The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

ATP-dependent chromatin-remodeling complexes are crucial for gene regulation, cell differentiation, and organ development in mammals.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

Stem cell niches support, regulate, and coordinate stem cell functions.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

Protoporphyrin IX is useful in cancer treatment but can cause health problems if not properly regulated.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.

Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.

Nerves and chemicals in the body can affect hair growth and loss.

Hair ages due to genetics and environmental factors, leading to graying and thinning, with treatments available for some conditions.

The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

No treatment fully prevents hair loss from chemotherapy yet.

Lichen planus pigmentosus causes dark skin patches and is treated by avoiding triggers and using anti-inflammatory medications.

Conditioned media from mesenchymal stem cell cultures could be a more effective alternative for regenerative therapies, but more research is needed.

Exosomes from dermal papilla cells can help grow hair and might treat hair loss.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

Targeting the skin's endocannabinoid system could help treat skin disorders.

Exosomes from dermal papilla cells help hair growth by making hair follicle stem cells multiply and change.

5-alpha reductase inhibitors can cause sexual side effects like erectile dysfunction and reduced sexual desire, sometimes lasting after stopping the drug.