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This study highlights the role of immune dysregulation, microRNA modulation, and SIRT1 pathways in alopecia areata, suggesting antisense oligonucleotides targeting miR-485-3p as a promising therapeutic strategy for promoting hair regrowth and reducing inflammation in murine models.

In this study, researchers prepared a humanized CXCL12 antibody for alopecia areata treatment, finding it significantly delayed disease onset in mice and reduced immune cell activation, suggesting potential as an immune modulatory therapy.

This article discusses how designing biomaterials to modulate immune responses has become a promising strategy for enhancing tissue repair and regeneration.

In this study, transplanted hair follicles from different body sites showed changes in morphology and immune status, suggesting their ability to adapt and function in new recipient areas such as the scalp or eyebrows.

This review discusses the role of fibroblasts in treating diabetic complications and wound healing, highlighting their potential as immunomodulatory factors but provides no new clinical results.

This study reports that AS101 induced hair growth in mice and suggests potential for treating chemotherapy-induced alopecia in humans, which was observed in case report studies with three adolescents.

This review discusses the use, mechanism, and side effects of topical immunomodulators in treating immune-mediated skin disorders and reports no new clinical results, urging further research on experimental agents.

In this retrospective cohort study, patients using leflunomide for primary autoimmune conditions showed a decreased risk of developing alopecia areata, while those using methotrexate, cyclosporine, and rituximab had an increased risk.

Leflunomide may reduce the risk of alopecia areata, while methotrexate, cyclosporine, and rituximab may increase it.

This case study reports a good response and tolerability for a combination treatment involving high potency topical corticosteroid, minoxidil 2%, LED, and inosine pranobex in a child with alopecia areata.

This case report describes a 19-year-old female with recurrent alopecia totalis who experienced complete remission after re-treatment with various therapies, emphasizing the importance of long-term follow-up in managing alopecia areata.

This study found that activating Toll-like receptor 3 signaling in periodontal ligament stem cells may enhance their immunomodulatory properties, suggesting potential implications for future stem cell therapy applications.

This study developed an all-natural hydrogel that promotes diabetic wound healing by converting pro-inflammatory M1 macrophages to anti-inflammatory M2 macrophages in a simple and biosafe manner.

This study found that a dietary intervention in dogs alleviated atopic dermatitis symptoms by modulating immune responses and skin microbiome composition compared to baseline, but with similar non-significant trends when compared with a positive control diet.

This study found that treating male rats with human hair follicle stem cells improved memory function impaired by streptozotocin and increased both neurotrophic and inflammatory markers, suggesting potential neuroprotective effects in this model.

This study found that systemic administration of NDP-MSH, a melanocortin receptor agonist, provided neuroprotective effects on dopaminergic nigrostriatal neurons in a mouse model of Parkinson's disease, reducing neuroinflammation and suggesting a role for regulatory T cells in these neuroprotective effects.

Dithranol reduces inflammation in alopecia areata by lowering certain immune responses.

The hydrogel helps heal diabetic wounds by combining antibacterial, antioxidant, and immune-boosting effects.

This chapter reveals how nano-antioxidants and immune-modulatory agents could offer innovative treatment strategies for PCOS by addressing the inflammation and immune system dysregulation often overlooked in traditional hormonal treatments.

This review reports that Dang Gui (Radix Angelica sinensis) possesses bidirectional immunoregulatory effects, enhancing immune cell proliferation and function, and may benefit immune-related diseases such as cancer and anemia. It also evaluates regulatory and safety aspects, aiming to guide future research and clinical use.

This study demonstrated that in mice, the absence of Jagged-1 expression in skin-resident regulatory T cells significantly delays wound healing by reducing the accumulation of neutrophils, highlighting the role of Jagged-1 in coordinating immune cell recruitment during injury.

This review highlights recent advancements in engineered probiotics for wound healing, reporting that genetically engineered strains of Lactobacillus reuteri and Lactococcus cremoris have shown promise in promoting faster wound healing in pre-clinical and clinical settings, particularly for diabetic foot ulcers.

This study found that nerve growth factor signaling in organ-cultured human hair follicles inhibits hair growth by inducing apoptosis-driven hair follicle regression.

This study found that specific TRPM5 modulators are unlikely to directly affect sebaceous glands, but safe TPPO analogues may provide moderate lipogenic and anti-inflammatory effects beneficial for dry skin conditions.

This review discusses progress in targeted therapies for vitiligo, focusing on Janus kinase inhibitors and the potential of mesenchymal stem cells, but reports no new clinical results.

This study reported that bioinks containing calcium molybdate nanoparticles and dermal papilla cells can promote hair regrowth in vivo by creating an anti-inflammatory environment and activating the mTOR signaling pathway in macrophages.

This study reported that a decellularized porcine amniotic membrane hydrogel can alleviate inflammation and promote tissue repair in a UVB-induced skin inflammation model, suggesting its potential as a regenerative treatment for photodamage-associated skin injuries.