Dynamic Immunomodulatory Nanoarchitectonics: Rewiring Tissue Regenerative Microenvironment via Intelligent Regulation

July 2025 in “ Nano Research ”

H. Y. Yuan, Bowen Li, Xuefei Shao, Yanguo Xi, Shixiang Cheng, Aifeng Liu, Bin Zheng

TLDR Nanotechnology can improve tissue healing by controlling immune responses.

The article explores the role of the immune microenvironment in tissue repair and regeneration, highlighting the importance of innate immune cell phenotypes in these processes. It emphasizes the potential of nanobiotechnology and biomaterials to modulate immune responses, thereby enhancing tissue regeneration. By designing biomaterials that create a pro-regenerative immune microenvironment, significant advancements in tissue engineering can be achieved. The article reviews the roles of immune cells in repairing bone, cartilage, and soft tissues, and discusses the latest developments in immunomodulatory nanosystems. It also addresses the challenges and future prospects of these nanomaterials in improving outcomes for patients with acute and chronic wounds.

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