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    Glossary Immune Dysregulation

    malfunctioning immune system attacking body's own tissues

    Immune dysregulation refers to an imbalance or malfunction in the immune system, where it either overreacts, underreacts, or attacks the body's own tissues. This can lead to various health issues, including autoimmune diseases like alopecia areata, where the immune system mistakenly targets hair follicles, causing hair loss.

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    1. Immune Dysregulation in Chronic Inflammatory Skin Disorders: An Integrative Immunopathological Review IECCMEXICO · 2026
    2. Rapidly Progressive Alopecia Universalis after Varicella-Zoster Virus Infection: The role of Immune Dysregulation and Tofacitinib treatment 2025
    3. Proteomic Profiling of Central Centrifugal Cicatricial Alopecia Reveals Role of Humoral Immune Response Pathway and Metabolic Dysregulation JID Innovations · 2024 · 5 citations
    4. Environmental Modulation of JAK3-Mediated Immune Dysregulation in Alopecia Areata Scholarly Commons (Embry–Riddle Aeronautical University) · 2025
    5. Dysregulation of the Immune System in a Natural History Study of 1299 Individuals with Down Syndrome Research Square (Research Square) · 2023
    6. A Case Study on Exploring Immune Dysregulation in Alopecia Areata - Mechanisms and Treatments Outcomes International Journal of Pharmaceutical Sciences Review and Research · 2025
    7. Baricitinib-Induced Remission of Alopecia Universalis in a Child with NFKB2-Associated Immune Dysregulation Journal of Clinical Immunology · 2025 · 2 citations
    8. Alopecia areata is characterized by dysregulation in systemic type 17 and type 2 cytokines, which may contribute to disease‐associated psychological morbidity 2019 · 57 citations
    9. Hidradenitis suppurativa: A folliculotropic disease of innate immune barrier dysfunction? Experimental dermatology · 2021 · 9 citations
    10. Early prediction of alopecia areata using machine learning modeling of neuro stress immune signatures from multi datasets Scientific Reports · 2025 · 1 citations
    11. A meta-analysis of chemokines in alopecia areata: recruiting immune cells toward the hair follicle Frontiers in Immunology · 2025 · 1 citations
    12. Biochemical Alterations and Immune-Inflammatory Responses in Alopecia Areata: A Case-Control Study kerbala journal of pharmaceutical sciences · 2026
    13. Androgenetic alopecia risk in allergic rhinitis: A cohort study of immune and antihistamine effects World Allergy Organization Journal · 2026
    14. Table 2_A meta-analysis of chemokines in alopecia areata: recruiting immune cells toward the hair follicle.docx Figshare · 2025
    15. Table 1_Integrated single-cell chromatin and transcriptomic analyses of peripheral immune cells in patients with alopecia areata.docx Figshare · 2025
    16. Disturbance of Immune Microenvironment in Androgenetic Alopecia through Spatial Transcriptomics International Journal of Molecular Sciences · 2024
    17. Features of the immune status and comorbidities in children with alopecia areata Medical Immunology (Russia) · 2023
    18. Transcriptional profiling in alopecia areata defines immune and cell cycle control related genes within disease-specific signatures Genomics · 2010 · 61 citations
    19. Exploring Emerging Concepts in the Pathophysiology of PCOS: Microbiome Dysbiosis and Immunological Dysregulation Reproduction and Fertility · 2026
    20. Regulation and dysregulation of hair regeneration: aiming for clinical application Cell Regeneration · 2022 · 2 citations
    21. Primary cicatricial alopecias are characterized by dysregulation of shared gene expression pathways PNAS Nexus · 2022 · 19 citations
    22. Assessment of Cytokine-Mediated Signaling Pathway Dysregulation in Arm Skin After CO2 Laser Therapy Journal of lasers in medical sciences · 2019 · 13 citations
    23. Alopecia Areata: An Updated Review for 2023 Journal of Cutaneous Medicine and Surgery · 2023 · 91 citations
    24. Metabolic syndrome and the skin: a more than superficial association. Reviewing the association between skin diseases and metabolic syndrome and a clinical decision algorithm for high risk patients Diabetology & Metabolic Syndrome · 2018 · 52 citations
    25. Long COVID: Clinical characteristics, proposed pathogenesis and potential therapeutic targets Frontiers in Molecular Biosciences · 2023 · 44 citations
    26. Post-COVID-19 Syndrome Mechanisms, Prevention and Management International Journal of Preventive Medicine · 2023 · 35 citations
    27. Stress and Psychoneuroimmunologic Factors in Dermatology Dermatologic Clinics · 2005 · 34 citations
    28. Janus kinase inhibition in Down syndrome: 2 cases of therapeutic benefit for alopecia areata JAAD case reports · 2019 · 32 citations
    29. Alopecia in Rhesus macaques correlates with immunophenotypic alterations in dermal inflammatory infiltrates consistent with hypersensitivity etiology Journal of Medical Primatology · 2010 · 23 citations
    30. Alopecia areata presenting in 2 kidney-pancreas transplant recipients taking cyclosporine Journal of The American Academy of Dermatology · 2005 · 23 citations