71 citations
,
May 1991 in “Clinical and Experimental Dermatology” Young men with male pattern baldness lose hair density over time without treatment.
59 citations
,
June 2022 in “Frontiers in medicine” This review discusses the complex causes and treatment challenges of chronic inflammatory skin diseases, emphasizing the need for biomarkers to predict treatment responses; it reports no new clinical results.
55 citations
,
August 2015 in “AAPS PharmSciTech” This study reports that a newly developed polyherbal phospholipid complex cream containing Citrus auranticum and Glycyrrhiza glabra extracts improved polyphenol retention in the skin, suggesting potential as an anti-aging cosmeceutical.
54 citations
,
November 2015 in “Methods in enzymology on CD-ROM/Methods in enzymology” This chapter reviews keratins in skin epithelia, including their roles in cellular function and disease, and reports no new experimental results.
43 citations
,
September 2001 in “Scanning” Hair treatments like bleaching increase friction by exposing tiny pores on the hair surface.
33 citations
,
May 2019 in “Aesthetic Plastic Surgery” This review found that most studies support the effectiveness and safety of using hyaluronic acid fillers and laser treatments together for facial rejuvenation, but highlights that the evidence is limited to small, nonrandomized studies and additional research is necessary.
33 citations
,
February 2021 in “Advanced Pharmaceutical Bulletin” This article explains the preparation methods and applications for various vesicle and particle systems used in transdermal drug delivery, highlighting their effectiveness and potential for further development in this field.
31 citations
,
January 1989 in “Clinical and Experimental Dermatology” In this study, topical 2% minoxidil did not significantly improve hair density measures in men with male pattern baldness, although there was no deterioration, suggesting a potential prophylactic effect.
30 citations
,
April 2017 in “Journal of structural biology” This study suggests that human keratin fiber matrix has a well-defined nano-scale grainy structure rather than being amorphous, with grain size influenced by chemical treatments, temperature, humidity, and follicle-level factors.
30 citations
,
August 1992 in “The Journal of Clinical Endocrinology and Metabolism” This study found that lowering serum DHT levels with 5 mg finasteride daily did not significantly alter serum gonadotropin levels in healthy young men after 28 days.
29 citations
,
November 2013 in “Expert Review of Dermatology” This article reviews potential causes and treatments for sensitive skin and reports no new clinical results; the authors emphasize neurogenic inflammation and cosmetic choices as key factors in managing the condition.
28 citations
,
April 1996 in “Cell biology international” This review discusses changes in keratin structure or gene expression that result in various skin disorders and reports no new clinical findings.
28 citations
,
February 2016 in “F1000Research” This review introduces an integrated view of hair follicle behavior, highlighting a Yin Yang model of regulation and suggesting glycans as key elements in hair follicle growth control, without reporting new clinical findings.
27 citations
,
September 2017 in “Journal of Medicinal Food” In this study, researchers found that a polyphenolic extract from Annurca apples, high in procyanidin B2, increased hair growth, density, and keratin content in healthy subjects after 2 months of use, and stimulated keratin biosynthesis in vitro.
20 citations
,
January 2003 in “Journal of oleo science” This study found that both everyday physical and environmental stresses, as well as chemical treatments, contributed to hair damage, with cuticle layers being more noticeably affected.
19 citations
,
April 2024 in “Journal of Umm Al-Qura University for Applied Sciences” This review explores the diverse roles of rosemary, covering its nutritional and medicinal uses, cosmetic and pharmaceutical applications, and evaluates various extraction methods, with a focus on sustainable practices and commercial prospects.
16 citations
,
September 2018 in “Journal of Ethnopharmacology” This review discusses the role of inheritance, androgens, and microinflammation in androgenetic alopecia and suggests some plant-based folk remedies may help address these factors but reports no new clinical results.
15 citations
,
March 2012 in “British journal of dermatology/British journal of dermatology, Supplement” This review discusses the role of shaving technology and specific skincare ingredients like glycerine and niacinamide in improving male facial skin health, but reports no new clinical results.
14 citations
,
March 1995 in “Journal of cell science” This study found that targeting SV40 T antigen expression to hair follicles in transgenic mice caused abnormal hair structure and hair loss, but did not lead to cell immortalization or tumor formation in follicles.
13 citations
,
March 2022 in “Cell Death and Differentiation” This study found that while autonomous Sema3A expression limited keratinocyte migration and delayed wound healing, non-autonomous application of recombinant Sema3A with EGF enhanced wound repair in mice.
13 citations
,
January 2020 in “Scientific Reports” This study found distinct differences in protein expression and wound healing pathways between Acomys cahirinus and Mus musculus, highlighting potential targets for reducing fibrotic response in mammals.
13 citations
,
July 2017 in “Biopolymers” This study presents recombinant human hair keratins K31 and K81, observing novel nanostructures from their self-assembly and emphasizing disulfide crosslinking's role in this process.
12 citations
,
December 2023 in “Journal of Applied Pharmaceutical Sciences and Research” In this research, caffeine's versatile pharmacological actions were highlighted, demonstrating its stimulant, bronchodilator, diuretic, and potential anticancer effects through interactions with adenosine receptors, phosphodiesterase, and renal tubules, revealing valuable insights for drug development and therapeutic applications in medicine.
12 citations
,
July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that hair follicle cells' growth in vitro is influenced by the concentration of androgens and antiandrogens, with papilla cells and outer root sheath keratinocytes showing distinct sensitivity.
10 citations
,
June 1998 in “International Journal of Dermatology” This article discusses inflammatory perifollicular fibrosis and alopecia but provides no new research findings.
8 citations
,
October 2023 in “Folia Histochemica et Cytobiologica” This study observed that exosomes from adipose mesenchymal stem cells overexpressing hepatocyte growth factor significantly improved liver function and reduced fibrosis in mice with experimentally induced liver injury.
8 citations
,
November 2022 in “International Journal of Cosmetic Science” This review discusses the limitations of current hair classification systems and highlights the need for standardized reporting of key hair characteristics to improve study comparisons; it reports no new results.
8 citations
,
January 2018 in “PubMed” The study reported that reducing finasteride particle size significantly improved its cellular permeation through prostate epithelial cells, though it had a lesser impact on systemic pharmacokinetics and tissue distribution in rats.
7 citations
,
December 2020 in “ACS biomaterials science & engineering” In this study, researchers demonstrated that human hair keratins can self-assemble into stable nanofibrous networks in vitro, which are compatible with human skin cells and useful for regenerative applications.
7 citations
,
August 2018 in “Journal of cosmetic dermatology” This study found that chemical hair straightening significantly reduced hair curl and improved smoothness and shine, but did not significantly affect transverse fissures or split ends, indicating potential benefits with some side effects.