Regulation of Semaphorin 3A in the Process of Cutaneous Wound Healing
March 2022
in “
Cell Death and Differentiation
”
TLDR Sema3A can both slow and speed up wound healing, depending on its form and combination with EGF.
The study explored the role of Semaphorin 3A (Sema3A) in cutaneous wound healing, revealing its complex effects on keratinocyte behavior. Sema3A adenovirus plasmids transfection limited keratinocyte proliferation and migration, while Sema3A depletion in mice delayed wound closure. Conversely, recombinant Sema3A proteins enhanced keratinocyte migration and accelerated wound closure. The study found that recombinant Sema3A, in combination with EGF, maintained EGFR activation through interaction with NRP1, suggesting that combined administration of EGF and Sema3A could improve wound healing outcomes. These findings highlighted the paradoxical role of Sema3A in wound repair and suggested potential therapeutic applications.
