1 citations
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February 2020 in “Drug Design Development and Therapy” Low-dose Minoxidil combined with Spironolactone helps reduce hair loss and improve hair density in women, with some mild side effects.
1 citations
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November 2016 in “Journal of the Dermatology Nurses’ Association” This article reviews the mechanism, use, and alternatives for finasteride in dermatology and provides no new clinical results.
July 2025 in “Carbohydrate Polymers” This study investigated the extracellular polysaccharides from the edible green alga Parachlorella sp. BX1.5, finding that they have potential applications in cosmetics and health products due to their stability, antioxidant properties, and effects on hair growth in mice.
March 2025 in “International Journal of Scientific Research” This study found that low-dose oral minoxidil effectively increased hair count over 24 weeks with mild reductions in blood pressure and minimal adverse effects among participants, suggesting its potential as a safe treatment for hair loss.
This literature review explores the mechanism of action, pharmacokinetics, safety, and efficacy of low-dose oral minoxidil as a treatment for various non-androgenic types of alopecia, finding it to be a promising alternative for these conditions despite the need to establish optimal dosing for different demographics.
February 2020 in “DOAJ (DOAJ: Directory of Open Access Journals)” In this study, a combination of low-dose minoxidil 0.25 mg and spironolactone 25 mg reduced hair shedding and improved hair density in patients with female pattern hair loss, with mild adverse effects.
April 2019 in “kufa Journal for Nursing sciences” This study observed that follicular unit extraction hair transplant initiated noticeable hair growth in androgenetic alopecia patients by three months and increased hair density after six months, with some experiencing mild side effects such as postural hypotension and donor site discomfort.
November 2022 in “DOAJ (DOAJ: Directory of Open Access Journals)” This case report describes a 39-year-old hypertensive and obese patient experiencing telogen effluvium potentially linked to a previous moderate COVID-19 infection, emphasizing the need for awareness of late symptoms associated with the disease.
February 2023 in “riUfes (Universidade Federal do Espírito Santo)” This study found that supraphysiological doses of testosterone alter endothelial relaxation pathways in hypertensive rats, with varied contributions from nitric oxide, prostanoids, and endothelium-derived hyperpolarizing factors, influenced by estrogen and dihydrotestosterone levels.
11 citations
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January 2018 in “Asian Journal of Andrology” Researchers observed that dutasteride and finasteride caused structural changes in the penises of both control and hypertensive rats, with dutasteride having a more pronounced effect on the corpus cavernosum.
November 2025 in “International Journal of Women’s Dermatology” This study found that pregnancy-associated skin disorders like pemphigoid gestationis are linked to increased risks of hypertensive disorders, gestational diabetes, and preterm complications, but atopic and pustular conditions show no such risks.
66 citations
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September 1982 in “Biochemical Pharmacology” This study identified a sulfotransferase activity in rat liver that catalyzes the sulfation of minoxidil, contributing to its delayed hypotensive effects.
40 citations
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July 2011 in “The journal of clinical hypertension” This article reviews the use of hydralazine, minoxidil, and sodium nitroprusside in managing hypertension and hypertensive crises, noting specific indications, adverse effects, and the adjunctive therapies needed to mitigate side effects.
24 citations
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August 2018 in “Journal of Ayurvedic and herbal medicine” In this review, the authors summarize the phytochemistry, pharmacology, and medicinal uses of Hibiscus rosa sinensis, highlighting its various benefits such as hypotensive and anti-inflammatory effects, while noting the need for more research on its specific mechanisms and potential toxicities.
18 citations
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February 2024 in “Nutrients” This study investigated a novel extract from pomegranate byproducts, finding it effective in reducing blood pressure and inflammation in hypertensive rats, comparable to Captopril, while also highlighting the extract's potential to enhance the pomegranate supply chain and environmental benefits.
5 citations
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January 2010 in “Medicinal Plants - International Journal of Phytomedicines and Related Industries” This review discusses the diverse pharmacological activities of T. procumbens, such as hypotensive and hair growth-promoting effects, but reports no new clinical findings.
February 2026 in “Journal of the American Academy of Dermatology” In this retrospective study, researchers found that while combination therapy of spironolactone and oral minoxidil for female alopecia commonly led to mild outpatient-manageable side effects, starting both medications simultaneously reduced hypertrichosis risk, but taking multiple blood pressure medications increased hypotensive symptoms.
In this study, low-dose oral minoxidil was found to have a favorable safety profile for treating alopecia, with mostly mild side effects, in both general and hypertensive populations.
155 citations
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October 2002 in “The FASEB Journal” This study found that altered testosterone metabolism and changes in cytochrome P450 mono-oxygenase expression are significantly associated with cardiac hypertrophy in human hearts and spontaneously hypertensive rats.
15 citations
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December 2016 in “Revista Da Associacao Medica Brasileira” This review examines the literature on polycystic ovary syndrome, focusing on its pathogenesis, diagnosis, and links to cardiovascular and hypertensive disorders, but presents no new clinical findings.
July 2024 in “Skin Appendage Disorders” In this study, researchers found that low-dose oral minoxidil for androgenetic alopecia in men generally showed a good safety profile, with hypertrichosis being the most frequent side effect, while systemic side effects like dizziness and hypotension were less common and no life-threatening effects were observed.
February 2024 in “Animals” In this study, dogs with adrenal-dependent hypercortisolism showed a decrease in the prevalence of systemic hypertension from 79% to 25% after a year of trilostane treatment or adrenalectomy, with blood pressure normalization observed by three months post-surgery in hypertensive dogs.
November 2017 in “International Journal of Biomedical and Advance Research - International Journal of Biomedical and Advance Research” This study reviews the ethnobotanical and pharmacological uses of Guazuma tomentosa, highlighting its diverse applications in traditional medicine and research findings that demonstrate its potential anti-diabetic, anti-hypertensive, anti-microbial, anti-oxidant, anti-ulcer properties, and more, in various animal models.
August 2016 in “Journal of Investigative Dermatology” This study observed that uncommon finasteride side effects included melasma, dry skin, tinnitus, postural hypotension, and oral lesions, with some symptoms persisting after treatment cessation.
22 citations
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January 1985 in “Annals of Internal Medicine” Minoxidil in breast milk may harm nursing infants.
45 citations
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November 1979 in “British Journal of Dermatology” This report describes a case of hypertrichosis associated with minoxidil use and suggests that nearly all patients on this drug may experience this side effect.
18 citations
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January 1976 in “Drugs” New treatments improved blood pressure control in patients with resistant hypertension.
October 2013 in “Journal of the American College of Cardiology” This study found that individuals with a nondipper blood pressure pattern had higher 24-hour urinary aldosterone levels, suggesting a possible link to heart issues.
January 2022 in “Al-Mağallaẗ al-ʻirāqiyyaẗ li-l-ṣaydalaẗ” This review discusses the efficacy and molecular pharmacology of topical minoxidil for hair loss and highlights innovations in delivery systems but reports no new clinical results.
January 2022 in “المجلة العراقية للصيدلة” In this review, researchers examined the molecular pharmacology and effects of topical minoxidil, noting its potential to treat androgenetic alopecia by enhancing hair regrowth, while also discussing advanced formulation methods like nanoemulsion and nanocarrier systems to improve its delivery.