70 citations
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November 2013 in “The BMJ” This study observed a temporal association between tamsulosin use for benign prostatic hyperplasia and an increased risk of severe hypotension requiring hospital admission during the first eight weeks of treatment initiation and restart.
58 citations
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January 2003 in “Biological & Pharmaceutical Bulletin” This study identified novel compounds from Bombax ceiba stem bark, including shamimicin, with potent hypotensive effects, and reported that a specific fraction had adverse effects on heart, liver, and kidneys in mice.
4 citations
,
March 2024 in “Journal of the American Academy of Dermatology” Spironolactone for skin issues rarely causes low blood pressure.
December 2023 in “Toxicology communications” This report describes a case of prolonged distributive shock attributed to minoxidil overdose, which involved intentional ingestion alongside trauma and NSAIDs, successfully managed with medications and hydration despite persistent low blood pressure.
37 citations
,
April 2002 in “The American Journal of Medicine” St. John's Wort can cause dangerous high blood pressure if taken with certain foods.
8 citations
,
January 2011 in “Korean Journal of Andrology” This study found that combining 4 mg doxazosin with 0.2 mg tamsulosin improved urinary symptoms with fewer vasodilatory side effects compared to a higher dose of doxazosin in hypertensive males with LUTS.
2 citations
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June 2025 in “Journal of the American Academy of Dermatology” Low-dose oral minoxidil can cause dizziness in women without lowering blood pressure, so careful monitoring is needed.
July 2025 in “Dermatology Practical & Conceptual” Spironolactone is safe for treating hair loss in women without causing low blood pressure.
July 2024 in “Journal of the American Academy of Dermatology” Low-dose oral minoxidil is generally safe for hypertensive patients with hair loss.
May 2022 in “Indian Journal of Pharmacology” This case report highlights a rare instance of valproate-induced hypertensive urgency in a 2-year-old girl, with improvement after stopping the medication.
April 2017 in “The journal of sexual medicine” This study investigated the effects of 5-alpha-reductase inhibitors on penile histomorphometry in both normotensive and hypertensive rats, reporting no significant changes between treated and untreated groups.
April 2017 in “The Journal of urology/The journal of urology” This study found that Sonic Hedgehog protein treatment enhanced the sprouting and regeneration of pelvic ganglia and cavernous nerves after injury, with localization of delivery affecting outcomes.
In this study, testosterone treatment was found to increase blood pressure in rats, potentially through mechanisms involving sodium and water retention in the kidneys and changes in specific gene expressions in the brain.
35 citations
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December 1979 in “Naunyn-schmiedebergs Archives of Pharmacology” These drugs raise prostaglandin-like material in dog blood, possibly causing blood vessel widening.
5 citations
,
March 2016 in “Acute medicine & surgery” This case report describes a man who ingested a large amount of topical minoxidil solution and experienced serious and prolonged cardiovascular effects despite rapidly decreasing serum concentration levels.
36 citations
,
July 2020 in “Frontiers in Medicine” Spironolactone might help protect against severe lung problems in COVID-19 patients.
43 citations
,
January 1977 in “Toxicology and Applied Pharmacology” In this study, minoxidil was found to have low toxicity in various animals, with specific heart lesions observed only in dogs at certain doses.
17 citations
,
April 1972 in “PubMed” Minoxidil lowers blood pressure and spreads throughout the body in normal rats.
5 citations
,
July 2016 in “Journal of Clinical Hypertension” This study found that hypertensive patients with severe androgenic alopecia exhibited impaired coronary microcirculation, suggesting they may face increased cardiovascular risk.
July 2025 in “Journal of Investigative Dermatology” Spironolactone can safely lower blood pressure in patients on other blood pressure medications, but may slightly increase the risk of low blood pressure.
March 2023 in “Clinical Toxicology” This correspondence highlights a case of intradermal minoxidil injection in a patient but does not report new research findings.
February 2023 in “Clinical Toxicology” This letter to the editor raises concerns about minoxidil, an arterial vasodilator also used for androgenic alopecia, noting that overdose can cause severe side effects such as distributive shock, pulmonary edema, and myocardial ischemia.
55 citations
,
March 1973 in “PubMed” Minoxidil is a new drug that lowers blood pressure.
43 citations
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May 1978 in “JAMA” Minoxidil controls blood pressure but may cause kidney damage and needs diuretics to prevent swelling.
22 citations
,
January 1979 in “JAMA” Minoxidil can lower blood pressure effectively and safely in emergencies.
3 citations
,
November 2025 in “Annals of Medicine” This study found that higher adherence to healthy dietary patterns such as DASH, AHEI, and MED significantly reduced all-cause mortality in hypertensive patients, with the DASH diet particularly lowering cardiovascular mortality, highlighting diet's role in hypertension management.
January 2024 in “Life sciences” This study observed that in spontaneously hypertensive rats, testosterone's effects on endothelium-dependent vasodilation involved reduced nitric oxide levels, increased oxidative stress, and greater reliance on endothelium-dependent hyperpolarization, with variations in these responses noted when testosterone was combined with either anastrozole or finasteride.
A medicine company has recalled a drug because it contained an unlisted blood pressure medication.
November 2017 in “Journal of Surgical Academia” This case report describes a woman with systemic lupus erythematosus who developed non-progressive visual field defects after hypertensive retinopathy, with cotton wool spots indicating retinal nerve fiber microinfarctions.
86 citations
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September 1977 in “BMJ” Minoxidil effectively controls blood pressure in severe cases, but has serious side effects and causes hair growth in women.