20 citations
,
February 1977 in “Circulation” Minoxidil lowers blood pressure and increases heart efficiency, but may raise lung artery pressure in some people.
26 citations
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June 1983 in “Journal of Hypertension” Minoxidil lowers blood pressure more effectively but has more side effects, so try hydralazine first.
49 citations
,
January 1980 in “Journal of Cardiovascular Pharmacology” Minoxidil doesn't increase pericardial disorder risk, but may cause fluid accumulation.
23 citations
,
November 1986 in “Pediatrics” Minoxidil, when used with a diuretic and β-blocking agent, can safely lower blood pressure in most children with severe hypertension due to kidney disease, with minimal side effects.
7 citations
,
October 2008 in “Arthritis Care & Research” This case report describes a 32-year-old woman with a history of undifferentiated connective tissue disease who presented with cardiogenic shock, and endomyocardial biopsy revealed giant cell myocarditis, possibly indicating an association with her autoimmune condition.
5 citations
,
February 1996 in “Clinical pharmacology and therapeutics/Clinical pharmacology & therapeutics” Minoxidil given intravenously caused small changes in diastolic blood pressure and increased heart rate at higher concentrations in patients with high blood pressure.
4 citations
,
February 2023 in “Research Reports in Clinical Cardiology” This study found that the ACE gene DD genotype and D allele are linked to an increased risk of hypertensive IHD complications, with dyslipidemia also identified as a significant risk factor for ischemic heart disease.
1 citations
,
January 1976 in “Clinical Science” This study concluded that minoxidil combined with a diuretic may effectively reduce blood pressure in moderately hypertensive male patients with minimal side effects.
March 2026 in “Critical Care Medicine” In this case study, treatment with methylene blue successfully improved blood pressure in a patient with refractory vasodilatory shock due to massive minoxidil ingestion, highlighting its potential as an adjunctive therapy.
October 2013 in “Journal of the American College of Cardiology” This review discusses the potential role of autonomic dysfunction and sympathetic overactivity in hypertension development and reports no new results; renal denervation therapies have gained popularity for resistant cases.
October 2013 in “Journal of the American College of Cardiology” Blood pressure that doesn't drop at night is linked to worse blood vessel function in people with high blood pressure.
31 citations
,
August 1975 in “Journal of Pharmaceutical Sciences” This study found that different species metabolized minoxidil into various products, with monkeys and humans showing similar profiles primarily excreting a glucuronide conjugate, while rats and dogs showed distinct differences.
March 2024 in “Journal of the American Academy of Dermatology”
11 citations
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March 2017 in “Journal of Biomedical Semantics” This study expands the Drug Ontology to include therapeutic indications for resistant hypertension, malaria, and opioid abuse research, providing a framework for additional drug use representations beyond their original design.
18 citations
,
January 1992 in “The Journal of emergency medicine” This case report describes a 20-year-old female who ingested an unknown quantity of minoxidil tablets in an overdose, presenting with cardiovascular symptoms, but her condition stabilized after supportive care.
16 citations
,
May 1982 in “Postgraduate Medical Journal” Minoxidil can cause pericardial and pleural effusions with high protein content.
6 citations
,
May 2020 in “Pharmacology Research & Perspectives” This study in rats found that a new hydroxypropyl-β-cyclodextrin formulation of minoxidil reduced the adverse cardiovascular and proliferative effects seen with traditional minoxidil solutions.
5 citations
,
January 2021 in “Journal of The American Academy of Dermatology” This article reflects on the history and significance of the FDA's approval of topical minoxidil for treating androgenetic alopecia in men and women, dating back to 1988 and 1991 respectively.
1 citations
,
December 2022 in “Indian pediatrics/Indian Pediatrics” A toddler who accidentally swallowed hair growth medicine experienced serious heart-related side effects but recovered after hospital treatment.
1 citations
,
February 2022 in “Veterinární Medicína” This report presents the first successful management of minoxidil toxicosis in a cat, detailing the clinical progression and treatment plan used to resolve the condition.
January 2015 in “International Journal of Pharma and Bio Sciences” This review discusses the traditional medicinal uses of Tridax procumbens, attributing its therapeutic properties to various active phytochemicals, but reports no new clinical findings.
May 2025 in “Modern technologies in ophtalmology” This research found that long-term use of minoxidil may rarely be associated with side effects unrelated to its known mechanism, though such effects are not well understood.
This case report details a 61-year-old man's overdose on oral minoxidil, resulting in systemic side effects like hypotension and edema, which resolved without intervention; similar symptoms were observed in 14 other patients after minoxidil ingestion.
October 2013 in “European Orthopaedics and Traumatology” A woman's hair grew back within 3 months after temporary hair loss from improper head positioning during shoulder surgery.
292 citations
,
April 2024 in “Nature Reviews Disease Primers” Early diagnosis and treatment of PCOS are crucial to reduce health risks and costs.
22 citations
,
January 1999 in “Journal of Toxicology Clinical Toxicology” This report describes the first documented case of an oral overdose of the extra strength 5% minoxidil solution, resulting in severe hypotension and requiring intensive medical intervention.
18 citations
,
March 2014 in “Current Pharmaceutical Biotechnology” This review discusses metformin's use in women with polycystic ovary syndrome, focusing on benefits during pre-conception and pregnancy, but reports no new clinical results.
16 citations
,
December 2011 in “Actas Dermo-Sifiliográficas” This review discusses the current understanding of propranolol's use in treating infantile hemangiomas, covering its indications, effectiveness, side effects, and ongoing clinical trials, without presenting new clinical results.
14 citations
,
September 2019 in “Eye” This review discusses the evidence for using oral medications to treat central serous chorioretinopathy, highlighting eplerenone as having the most support despite a lack of robust efficacy across studies.
13 citations
,
December 2010 in “Nature Reviews Endocrinology” A young man with an eating disorder had a life-threatening adrenal crisis due to an autoimmune condition, highlighting the need for better education on managing hormone treatments.