Minoxidil Versus Nitroglycerin: A Prospective Double-Blind Controlled Trial in Transcutaneous Erection Facilitation for Organic Impotence

July 1991 in “ The Journal of Urology ”

Giorgio Cavallini

minoxidil nitroglycerin placebo organic impotence neurogenic impotence Rogaine

Studysummary This study found that topically applied minoxidil was more effective than nitroglycerin and placebo in enhancing penile diameter, rigidity, and arterial flow, with the most pronounced effects in patients with neurogenic impotence. Our plain-language summary of this paper — not a Tressless recommendation.

A study conducted 31 years ago compared the effectiveness of topically applied minoxidil, nitroglycerin, and a placebo in facilitating erections in patients with organic impotence. The study found that minoxidil was more effective than nitroglycerin and placebo in increasing diameter, rigidity, and arterial flow of the penis. The highest activity was found in neurogenically impotent patients, and fewer side effects were found with minoxidil than with nitroglycerin. The study proposes minoxidil as a long-term therapeutic agent for organic impotence.

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Research cited in this study

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research Hair Follicle Biology and Topical Minoxidil: Possible Mechanisms of Action

37 citations , October 2009 in “Dermatology”

This study suggests that the action of minoxidil in stimulating hair growth likely occurs at the follicular dermal papilla, though it does not induce new follicle formation.

research Electrophysiological Mechanisms of Minoxidil Sulfate-Induced Vasodilation of Rabbit Portal Vein

47 citations , October 1989 in “Circulation Research”

The study explains how minoxidil sulfate causes vasodilation in rabbits by opening potassium channels and inhibiting calcium channels.

research Retinoids: Compounds Important to Hair Growth

19 citations , October 1988 in “Clinics in dermatology”

This article discusses potential roles for retinoids in hair regrowth and proposes future studies, reporting no new experimental results.

research Topical Minoxidil for Hair Growth in Alopecia Areata and Androgenetica

24 citations , February 1987 in “Drugs”

Minoxidil promotes hair regrowth, but more research needed for effectiveness and response factors.

research Effects of Minoxidil on Cultured Human Skin Fibroblasts

19 citations , January 1987 in “Dermatology”

This review discusses the effects of minoxidil on human skin fibroblasts, reporting its potential to inhibit lysyl hydroxylase activity and DNA synthesis, suggesting it may have antifibrotic applications for collagen-related skin conditions.

research Effect of Minoxidil on Cultured Keratinocytes

72 citations , December 1983 in “Journal of Investigative Dermatology”

Minoxidil helps hair cells live longer and grow longer.

research Reversal of Baldness in Patient Receiving Minoxidil for Hypertension

95 citations , December 1980 in “The New England Journal of Medicine”

Minoxidil helped bald patient regrow hair.