Minoxidil Sulphation in Human Liver and Platelets

November 1993 in “ European journal of clinical pharmacology ”

Gian Maria Pacifici, R. Bigotti, G. De Marchi, L. Giuliani

minoxidil minoxidil sulphation phenol sulphotransferase hair growth hypotensive metabolic processing Rogaine

TLDR Minoxidil is processed in the body by an enzyme found in the liver and platelets.

The document discussed the enzymatic process of minoxidil sulphation in human liver and platelets. It highlighted the role of phenol sulphotransferase in this biochemical pathway, emphasizing the enzyme's distribution and activity in different human tissues. The study provided insights into the metabolic processing of minoxidil, a drug known for its hypotensive and hair growth-promoting properties. The findings contributed to understanding how minoxidil is metabolized in the body, which could have implications for its therapeutic use and effectiveness.

View this study on link.springer.com →

Discuss this study in the Community →

Research cited in this study

8 / 8 results

research Localization of Minoxidil Sulfotransferase in Rat Liver and the Outer Root Sheath of Anagen Pelage and Vibrissa Follicles

46 citations, January 1991 in “Journal of Investigative Dermatology”

Minoxidil works in liver and outer hair root sheath for hair growth.

Sulfation of Minoxidil by Human Liver Phenol Sulfotransferase

research Metabolism of Minoxidil, a New Hypotensive Agent: Biotransformation Following Oral Administration to Rats, Dogs, and Monkeys

31 citations, August 1975 in “Journal of Pharmaceutical Sciences”

Minoxidil metabolizes similarly in monkeys and humans, but differently in dogs and rats.

research Pharmacologic Properties of Minoxidil: A New Hypotensive Agent

55 citations, March 1973 in “PubMed”

Minoxidil is a new drug that lowers blood pressure.

Related Research

7 / 7 results

Minoxidil Sulfotransferase Enzymatical Activity in Plants: A Novel Paradigm in Increasing Minoxidil Response in Androgenetic Alopecia

research Minoxidil Sulfotransferase Enzymatical Activity in Plants: A Novel Paradigm in Increasing Minoxidil Response in Androgenetic Alopecia

August 2023 in “Journal of Cosmetic Dermatology”

Some plants like spinach, broccoli, and matcha may boost the effectiveness of the hair growth drug minoxidil.

research Tretinoin Enhances Minoxidil Response in Androgenetic Alopecia Patients by Upregulating Follicular Sulfotransferase Enzymes

8 citations, April 2019 in “Dermatologic Therapy”

Tretinoin boosts minoxidil's effect on hair loss by increasing enzyme activity.

research The Use of Minoxidil in the Treatment of Male and Female Androgenetic Alopecia: A Story of More Than 30 Years

5 citations, January 2018 in “Italian journal of dermatology and venereology”

Comparative Study Between 2% Minoxidil Topical Spray vs. Intradermal Injection for Treatment of Androgenetic Alopecia in Female Patients: A Controlled, 4-Month Randomized Trial

research Comparative Study Between 2% Minoxidil Topical Spray vs. Intradermal Injection for Treatment of Androgenetic Alopecia in Female Patients: A Controlled, 4-Month Randomized Trial

1 citations, January 2010

Mesotherapy is more effective than topical spray for female hair loss treatment.

A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

research A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

269 citations, August 2002 in “Journal of The American Academy of Dermatology”

5% minoxidil works better for hair growth and density, with minor irritation.

research Androgenetic Alopecia: Treatment Results with Topical Minoxidil

39 citations, March 1987 in “Journal of The American Academy of Dermatology”

Topical minoxidil is a safe and effective treatment for hair loss caused by androgenetic alopecia.

research Sulfation of Minoxidil by Liver Sulfotransferase

66 citations, September 1982 in “Biochemical Pharmacology”

Liver enzyme helps minoxidil work better for blood vessel relaxation.

Minoxidil Sulphation in Human Liver and Platelets

Research cited in this study

research Localization of Minoxidil Sulfotransferase in Rat Liver and the Outer Root Sheath of Anagen Pelage and Vibrissa Follicles

research Sulfation of Minoxidil by Human Liver Phenol Sulfotransferase

research Minoxidil Stimulates Mouse Vibrissae Follicles in Organ Culture

research Sulfation of Minoxidil by Human Platelet Sulfotransferase

research Dose-Response Study of Topical Minoxidil in Male Pattern Baldness

research Minoxidil: A Review of Its Pharmacological Properties and Therapeutic Use

research Metabolism of Minoxidil, a New Hypotensive Agent: Biotransformation Following Oral Administration to Rats, Dogs, and Monkeys

research Pharmacologic Properties of Minoxidil: A New Hypotensive Agent

Related Community Posts Join

community "Minoxidil and Caffeine: Reason behind hyper responders and non-responders."

community Sugars ARE important for hair growth | Glycosaminoglycans as Hair Growth Stimulant

community Comprehensive Microneedling Guide

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

community How is it possible for someone to be a non responder to ORAL minoxidil?

community Average tressless user after taking oral minoxidil