April 2020 in “The FASEB Journal” This study found that blocking the hypothalamic-pituitary-gonadal axis in male rats reduced baroreflex dysfunction and inflammation caused by endotoxemia, highlighting potential therapeutic benefits.
20 citations
,
June 1985 in “Toxicologic Pathology” In this study, prolonged high-dose steroid treatment in rats caused several pathological changes, some of which regressed, particularly improvements in mammary gland tumors and pituitary-related symptoms, after stopping treatment.
2 citations
,
July 2021 in “Journal of feline medicine and surgery open reports” In this case study, treatment with cabergoline in a diabetic cat with hyperadrenocorticism was associated with diabetic remission and improved clinical signs.
21 citations
,
December 1997 in “The Journal of Dermatology” In this case report, a 57-year-old Japanese woman with alopecia areata, associated with myasthenia gravis and thymoma, showed significant improvement after undergoing thymectomy and receiving high doses of glucocorticosteroids.
July 2022 in “International Medical Case Reports Journal” This report details a 6-year-old girl with adrenocortical cancer presenting with voice changes, weight gain, and excessive hair growth, successfully treated with surgery and medication, with symptoms resolved after 6 months.
119 citations
,
October 1998 in “Endocrinology” This study found that normalizing mineral ion levels in vitamin D receptor-ablated mice prevented hyperparathyroidism, rickets, and osteomalacia, but alopecia persisted, indicating a separate role for the receptor in hair growth.
3 citations
,
July 2021 in “Aesthetic Plastic Surgery” This case series observed that the combination of platelet-rich plasma and fat grafting improved hair quality and density in patients with non-scarring alopecia, with effects visible by 12 weeks and sustained up to one year.
3 citations
,
January 2011 in “Indian Journal of Dermatology Venereology and Leprology” This study found that an adjusted dosing regimen of oral betamethasone led to complete hair regrowth in an 8-year-old with alopecia totalis, without observed side effects.
October 2025 in “Medicine” This case report presents a patient with idiopathic isolated ACTH deficiency and testicular germ cell tumor, with alopecia areata as an initial symptom, suggesting a potential link between these conditions.
2 citations
,
October 2015 in “The New England Journal of Medicine” This case report describes a 57-year-old woman with hirsutism, hair loss, and vocal changes, who was found to have elevated testosterone levels but normal dehydroepiandrosterone sulfate levels.
28 citations
,
May 2014 in “PubMed” This study found that increased hair cortisol levels, indicating stress, were associated with greater hair loss in captive rhesus macaques, although the causality of this relationship remains unclear.
22 citations
,
January 2019 in “Climacteric” This study reports that oophorectomy significantly reduces serum testosterone levels in postmenopausal women, indicating the postmenopausal ovary's continued production of testosterone.
This study found that switching juvenile mice from a high-fat, high-carbohydrate diet to a control diet optimally reduced hormonal imbalances and weight, with nutraceuticals offering partial support.
2 citations
,
January 2018 in “PubMed” This case report describes a 45-year-old man with a pituitary macroadenoma whose symptoms and tumor size improved significantly after one month of treatment with cabergoline.
7 citations
,
May 2012 in “International Journal of Andrology” This study found that an oral testosterone formulation normalized serum testosterone levels and significantly reduced SHBG in men with experimentally induced hypogonadism after nine days of treatment, suggesting potential efficacy for testosterone deficiency.
5 citations
,
October 2003 in “PubMed” This case report describes a 30-year-old male with a late diagnosis of Kallmann's syndrome, highlighting the necessity of hormonal therapy to reduce the risk of osteoporosis and bone fractures despite the patient's acceptance of his physical appearance.
12 citations
,
January 2009 in “Gynecological Endocrinology” This case report identified ovarian hyperthecosis as the cause of recent-onset androgenic symptoms in a 73-year-old woman, which was confirmed by ovary removal and led to symptom improvement.
8 citations
,
June 2017 in “Hormone Molecular Biology and Clinical Investigation” This study found that subclinical hypothyroidism had minimal impact on the metabolic and hormonal profiles of women with polycystic ovary syndrome.
4 citations
,
February 2025 in “GeroScience” This study found that restoring hypothalamic NPY levels in mice delayed aging-related characteristics such as fat loss, hair loss, and memory decline, suggesting that maintaining these levels could be important for counteracting aging and its effects.
May 2021 in “Journal of the Endocrine Society” In this case report, an established Hashimoto's thyroiditis patient converted to Graves disease, highlighting the need for regular monitoring and thyroid function tests to distinguish from potential levothyroxine over-replacement.
April 2023 in “Journal of Investigative Dermatology” In this study, hair follicle-associated pluripotent stem cells from transgenic mice successfully normalized hair follicles and stimulated hair growth in athymic nude mice, indicating potential for cellular hair-loss therapy.
April 2020 in “Journal of the Endocrine Society” This case report highlights Leydig cell hyperplasia as a rare cause of increased testosterone and postmenopausal hirsutism, resolved after bilateral salpingo-oophorectomy in a 64-year-old woman.
May 2021 in “Journal of the Endocrine Society” This report presents a rare case of suspected 3β HSD deficiency in an adult female with symptoms like male pattern hair loss and low testosterone, suggesting a non-classical presentation.
1 citations
,
January 2013 in “International journal of trichology” The researchers reported a case of a young girl with alopecia areata who responded well to a combination therapy of 88% phenol and dexamethasone, with no recurrence observed during six months of follow-up.
October 2024 in “Journal of the Endocrine Society” This case report details a postmenopausal woman whose hyperandrogenism was attributed to ovarian stromal hyperplasia, ultimately resolved with bilateral salpingo-oophorectomy.
August 2026 in “European Journal of Endocrinology” In this case report, researchers described how autoimmune thyroid disease can obscure primary hyperparathyroidism diagnosis, emphasizing the necessity of combining imaging, cytology, biochemical assessment, and parathyroid scintigraphy for accurate diagnosis.
15 citations
,
April 2022 in “Ginekologia Polska” Higher thyroid hormone levels may be linked to certain types of polycystic ovary syndrome.
80 citations
,
October 1985 in “American Journal of Public Health” This study found significant weight loss and reductions in blood pressure and serum triglycerides among obese patients following a multidisciplinary program with a very low calorie ketogenic diet.
49 citations
,
October 1988 in “The Journal of Clinical Endocrinology & Metabolism” This study found that low doses of leuprolide effectively suppressed serum estradiol and LH response, while higher doses were needed to suppress testosterone and reduce hair growth in hirsute women.
January 2024 in “Case Reports in Endocrinology” In this case report, significant improvements in a 58-year-old male with severe refractory myasthenia gravis and concurrent alopecia areata were observed following a cortisone taper, suggesting a potential therapeutic role, especially after thymectomy.