Regression of Pathological Changes Induced by Long-Term Administration of Contraceptive Steroids to Rodents

June 1985 in “ Toxicologic Pathology ”

George Lumb, Lorelie Mitchell, Felix A. de la Iglesia

contraceptive steroids quingestanol acetate quinestrol hair loss pituitary enlargement mammary chain masses adenocarcinoma ovarian atrophy uterine atrophic changes

TLDR Some steroid-induced health issues in rodents improved after stopping treatment, but hair loss and eye problems did not.

The study investigated the effects of long-term administration of contraceptive steroids, specifically quingestanol acetate and quinestrol, on rodents over 50 weeks, followed by a 30-week observation period. The treatment led to several adverse effects, including hair loss, ataxia due to pituitary enlargement, mammary chain masses with adenocarcinoma, lens opacities, ovarian atrophy, and uterine atrophic changes. After cessation of treatment, some conditions, such as mammary gland tumors and ataxia, showed regression, while hair loss and lens opacities persisted. The study highlighted the potential for regression of certain steroid-induced pathologic changes, although tegumentary and ocular changes remained unaffected.

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