Kallmann's Syndrome: Skeletal and Psychological Aspects of Late Diagnosis

This case study reported on a 30-year-old male with Kallmann's syndrome (KS), characterized by hypogonadotropic hypogonadism and hypoosmia, who was diagnosed unusually late. The patient exhibited severe skeletal issues, including scoliosis and kyphosis, and lacked typical male secondary sexual characteristics. Despite his acceptance of his physical appearance, hormonal therapy with hCG was deemed necessary to mitigate the risk of osteoporosis and bone fractures. Initial treatment with low-dose hCG improved testosterone levels and bone density, and the dose was later increased. Psychological support was also provided to address the patient's concerns. The study concluded that hormonal therapy is crucial in late-diagnosed KS to prevent further skeletal complications.