Kallmann's Syndrome: Skeletal and Psychological Aspects of Late Diagnosis

The document reported a case of Kallmann's syndrome (KS) in a 30-year-old Caucasian male who was diagnosed late with hypogonadotropic hypogonadism and hypoosmia. The patient had a history of rickets, rapid growth, and presented with back pain and decreased exercise tolerance. Physical examination revealed hypogonadism, hypoosmia, severe scoliosis, kyphosis, and chest malformations. Despite the patient's acceptance of his physical appearance, hormonal therapy was deemed necessary to reduce the risk of osteoporosis and bone fractures. Treatment with low doses of hCG and vitamin D and calcium supplementation improved bone density and relieved pain. After six months, the hCG dose was increased. The study concluded that even with late diagnosis, hormonal therapy is crucial to prevent further skeletal malformations and health complications.