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This study found that fibroblasts from Emery-Dreifuss muscular dystrophy patients with certain genetic mutations overexpress markers of fibrosis, and gene correction techniques reduced fibrogenic molecule expression in cell models, suggesting potential therapeutic applications.

This review highlights the role of matriptase in epithelial differentiation and cancer, noting that unregulated matriptase expression can enhance cancer progression in animal models, but reports no new experimental data.

This study found that squamous cell carcinomas from hair follicle stem cells are more prone to epithelial to mesenchymal transition and metastasis than those from interfollicular epidermis, due to distinct chromatin landscapes.

This study suggests that phenotypic plasticity, including processes like dedifferentiation and transdifferentiation, plays a crucial role in cancer initiation, progression, and therapy resistance, broadening our understanding of cancer dynamics and potential treatment strategies.

This study observed that retinoic acid biosynthesis and signaling in hair follicles have a spatial and temporal regulation linked to distinct stages of the hair cycle in mice.

Keratin proteins in epithelial cells are dynamic and crucial for cell processes and disease understanding.

This study found that mutant cells in hair follicles can be tolerated or eliminated by surrounding normal tissue, suggesting the potential for wild-type cells to counteract oncogenic mutations.

This study suggests that heparan sulfate is crucial for regulating hair follicle formation, cycling, and gland morphogenesis, with its ablation leading to continuous hair growth and increased gland activity in mice.

In this study using SKH-1 mice, researchers observed that acute UVB exposure increased expression of retinoid metabolism proteins and decreased retinol storage enzyme levels, suggesting enhanced retinoic acid synthesis in the epidermis.

A woman experienced fluctuating thyroid conditions and eye disease, but her symptoms improved with treatment.

This study found that excess vitamin A in organ cultures of mouse embryos led to significant changes in epidermis and hair follicles, altering morphogenesis and polysaccharide distribution.

This review discusses the role of the EGF receptor/ligand system in skin homeostasis and its implications for keratinocyte stem cells and reports no new clinical results.

In this study, the misshaped and hairy ear phenotype in mutant mice was linked to mis-expression of certain Hoxc genes due to a chromosomal inversion.

This study demonstrated that VD3 significantly enhanced the proliferation and differentiation of epidermal stem cells in a murine skin defect model, leading to improved wound healing, potentially through activation of the PI3K signaling pathway.

This review discusses the unique characteristics and possible pathophysiology of spiny keratoderma, reporting no new clinical results, but suggests that some therapies might alleviate symptoms.

This study found that keratin derivatives with functionalized thiol groups improved binding to both natural and bleached hair fibers, suggesting a promising strategy for enhancing keratin's durability in hair repair.

In a transgenic mouse model, this study found that overexpression of keratin 16 in skin keratinocytes led to hyperkeratosis and increased EGF receptor signaling, altering skin cell behavior and structure.

This study established a mouse model for Cushing's syndrome due to a specific Crh mutation, which may help explore the effects of glucocorticoid excess and evaluate treatments for corticosteroid-induced osteoporosis.

This study reports a case of GGCX syndrome in a 55-year-old Japanese male, characterized by PXE-like symptoms and coagulation deficiency, with an unreported phenotype of possible spinocerebellar degeneration.

In this study, epidermal EGFR ablation in a mouse model led to significant local and systemic inflammatory responses, highlighting EGFR's role in maintaining skin immuno-homeostasis.

This study found that combining Alexandrite laser with iontophoresis of chymotrypsin and papain enzymes reduced the laser pulse requirements compared to laser alone for treating paradoxical hypertrichosis in women with facial hirsutism, suggesting potential clinical benefits in managing this condition.

This study found that using electronic healthcare record data can provide valuable early insights into the clinical context of about half of the new safety signals evaluated within a regulatory environment.

This case report describes a unique lesion in a 10-month-old girl, characterized by increased eccrine glands and hair follicles, leading to the proposed term "hybrid eccrine gland and hair follicle hamartoma".

In this study, injecting chimeric RNA–DNA oligonucleotides into mice skin caused a temporary mutation in keratin 17, altering hair morphology, but the mutation was transient due to genetic compensation or cell replacement.

This study investigated AHR signaling's role in skin biology and reported that novel AHR ligands may help restore keratinocyte function and reduce inflammation in skin diseases, suggesting their potential as therapeutic agents.

This study found that LepRb neurons in the brain are important targets for androgen action and influence sex-specific differences in reproductive and metabolic regulation, implicating them in conditions such as polycystic ovary syndrome.

In this study, researchers observed that different ERK signal activation dynamics during hair follicle regeneration are linked to cell fate specification and are affected by distinct upstream signaling pathways.

This study demonstrates that polarized second harmonic generation imaging effectively monitors wool fiber stretching, revealing significant structural changes in keratin alignment that improve textile performance.

This study found that specific gene upregulations and mutations in hidradenitis suppurativa skin support the role of inflammation, altered epithelial differentiation, and metabolism dysregulation in the disease's pathogenesis.