TLDR Spiny keratoderma is a rare skin condition with small spines on palms and soles, possibly linked to abnormal hair formation.
Spiny keratoderma was a rare skin condition characterized by small keratin spines on the palms and soles, representing columns of hyperkeratosis. It was thought to result from enhanced epidermal proliferation in the basal layer. The condition had several forms, including familial, sporadic, postinflammatory, and paraneoplastic, with some patterns associated with malignancies. Treatment options included topical vitamin D, combinations of 5-fluorouracil or retinoids with ammonium lactate, and physical lesion removal. The condition might have been a form of ectopic hair formation, although abortive.
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January 1999 in “Journal of Cutaneous Pathology” Spiny keratoderma may be ectopic hair formation on palms and soles.
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December 2023 in “International journal of molecular sciences” Understanding keratinization is crucial for treating skin conditions like ichthyoses and psoriasis.
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April 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” MendelVar is a tool that helps identify important genes by combining GWAS data with Mendelian disease information.
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January 2013 in “Elsevier eBooks” The document explains the genetic causes and characteristics of inherited hair disorders.
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January 2014 in “Springer eBooks” The book details skin conditions in older adults, their link to mental health, cancer treatment importance, hair loss remedies, and managing autoimmune and itchy skin.
January 2017 in “Springer eBooks” The document explains various skin conditions and their treatments.
