192 citations
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January 1976 in “The Journal of Clinical Endocrinology & Metabolism” This study observed that androgen levels rise with pubic hair development in Tanner stages, differing by sex and age, with DHEA showing a significant prepubertal increase especially in precocious adrenarche.
1 citations
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January 1971 Hormones, especially androgens, affect hair growth and can cause hair loss or excess hair in both men and women.
34 citations
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February 2013 in “The Journal of Clinical Endocrinology and Metabolism” This study estimates the prevalence of hyperandrogenic states in late adolescent and young females, revealing that these disorders often begin at a young age.
52 citations
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November 2009 in “International journal of gynaecology and obstetrics” This study found that hyperandrogenemia in Chinese women with PCOS is associated with higher risks of type 2 diabetes and obesity, suggesting it should be prioritized in managing PCOS-related infertility.
2 citations
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December 2016 in “Journal of Pakistan Association of Dermatology” This study found that serum androgen levels were associated with the severity of hirsutism in women, with significantly higher levels observed in those with moderate to severe hair growth.
October 2024 in “Journal of the Endocrine Society” In this case study, a postmenopausal woman with symptoms of virilization was diagnosed with a rare ovarian Leydig cell tumor, and surgical removal led to a resolution of her hyperandrogenism and related symptoms, highlighting the importance of thorough differential diagnosis in postmenopausal hyperandrogenism.
12 citations
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December 2005 in “PubMed” This study suggests that some men with premature androgenic alopecia may have hormonal profiles similar to women with polycystic ovary syndrome, potentially indicating a male equivalent of the condition.
5 citations
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July 1998 in “PubMed” This article reviews androgenic disorders in women, such as PCOS, highlighting how understanding these conditions could improve their management, but it presents no new clinical findings.
October 2025 in “Journal of the Endocrine Society” This case study reported a unique instance of a benign adrenal adenoma co-secreting cortisol and DHEA-S, which initially mimicked PCOS symptoms. Surgical removal resulted in significant clinical improvement, confirming the diagnosis of cyclic adrenal Cushing's syndrome.
2 citations
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September 2002 in “Journal of Endocrinological Investigation” The GH-IGF-I axis is likely involved in the hormonal imbalances seen in non-obese women with functional hyperandrogenism.
67 citations
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February 2010 in “Acta Obstetricia et Gynecologica Scandinavica” In this study, hirsutism in women with PCOS was strongly associated with hyperandrogenism and metabolic abnormalities, while acne and androgenic alopecia were not effective markers for hyperandrogenism.
6 citations
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March 1982 in “Clinical and Experimental Dermatology” This article discusses primary cutaneous virilism, focusing on alopecia in women with androgen-dependent skin conditions, and reports no new findings.
May 2021 in “Journal of the Endocrine Society” This study found that the severity of female pattern hair loss in premenopausal women was associated with clinical signs of hyperandrogenism, such as hirsutism and acne, but not with biochemical parameters.
April 2025 in “The Journal of Clinical Endocrinology & Metabolism” This study highlights the global prevalence of hirsutism in women and reviews its diagnostic criteria, potential underlying causes like polycystic ovary syndrome, and treatment options, emphasizing the need for tailored, multifaceted management and acknowledging the distress it causes patients.
2 citations
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October 2015 in “The New England Journal of Medicine” This case report describes a 57-year-old woman with hirsutism, hair loss, and vocal changes, who was found to have elevated testosterone levels but normal dehydroepiandrosterone sulfate levels.
60 citations
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September 2001 in “Journal of the American Academy of Dermatology” This review discusses the relationship between insulin regulation and hyperandrogenemia in polycystic ovary syndrome, suggesting potential benefits of insulin-lowering treatments for ovarian function but reporting no definitive results for hair-related symptoms.
7 citations
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January 2014 in “Case reports in endocrinology” This case report describes a testosterone- and cortisol-secreting adrenocortical oncocytoma causing hirsutism in a 23-year-old woman, highlighting adrenal oncocytomas as an important consideration for differential diagnosis.
3 citations
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December 2019 in “Journal of Dermatological Treatment” This study observed that adult female acne may be associated with hyperandrogenic features and polycystic ovary syndrome, though routine hormonal tests often do not show abnormalities other than PCOS.
April 2020 in “Journal of the Endocrine Society” This case report describes a 58-year-old woman whose virilization symptoms were linked to a steroid tumor of the ovary, emphasizing the importance of prompt diagnosis and treatment to improve her quality of life.
June 2013 in “Lithuanian University of Health Sciences” This study found no significant relationship between hormone levels and sexual function in young women with hirsutism compared to a control group.
7 citations
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August 2012 in “The Journal of Urology” This study found that despite androgen excess and genitourinary masculinization, adult women with congenital adrenal hyperplasia did not exhibit notable prostatic growth.
In this study, hyperandrogenemia was observed in 78.2% of Greek women with polycystic ovary syndrome, with testosterone being the most commonly elevated androgen and acne the most frequent clinical feature.
12 citations
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July 2020 in “DOAJ (DOAJ: Directory of Open Access Journals)” This review evaluates the hormonal, metabolic, and clinical aspects of a male equivalent PCOS syndrome in men and highlights areas where further research is needed, reporting no new empirical findings.
November 2022 in “Journal of the Endocrine Society” This case study reports that in an 8-year-old male, a pituitary adenoma causing isolated high LH secretion led to early testosterone-driven puberty without typical testicular enlargement, highlighting the differential roles of LH and FSH in pubertal development.
October 2024 in “Journal of the Endocrine Society” In this case report, researchers described a postmenopausal woman with virilization symptoms who was diagnosed with a Leydig cell tumor in her ovary, and symptoms improved following tumor removal. The authors highlighted the diagnostic challenge of differentiating such cases from age-related hormonal changes.
October 2024 in “Journal of the Endocrine Society” In this case report, the authors describe the diagnosis and management of a rare case of hyperandrogenism in a postmenopausal woman, attributed to coexisting ovarian Leydig cell and Brenner tumors, with improvement in symptoms following bilateral salpingo-oophorectomy.
3 citations
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May 2002 in “PubMed” This article reviews the causes and treatments of hypertrichosis and hirsutism and reports no new clinical findings; the authors compare diagnostic strategies and discuss available treatment options.
2 citations
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May 2018 in “Diagnosis” This case report presents a rare instance of an ovarian steroid cell tumor in a 68-year-old female with virilism, which normalized androgen levels following surgical removal.
3 citations
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January 2019 in “JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH” This study found that idiopathic hirsutism was the most common cause of hirsutism among patients, and insulin resistance was significant in those with Hyperandrogenic Insulin Resistant Acanthosis Nigricans Syndrome.
13 citations
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January 1995 in “Postgraduate medicine” This article outlines common and serious causes of excessive body hair in women, noting that benign conditions like polycystic ovarian syndrome are treatable, while dangerous causes require swift medical attention; it reports no new results.