GH-IGF-I Axis in Non-Obese Women with Functional Hyperandrogenism

    September 2002 in “ Journal of Endocrinological Investigation ”
    Mateja Legan, A Kocijancic, Janez Prezelj, Joško Osredkar, Sanne Fisker
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    TLDR The GH-IGF-I axis is likely involved in the hormonal imbalances seen in non-obese women with functional hyperandrogenism.
    The study examined the GH-IGF-I axis in 18 non-obese women with functional hyperandrogenism (FH) and compared their hormone levels to those of 10 weight-matched controls. The researchers measured various hormone levels, including GH, GHBP, IGF-I, and androgens, and found that non-obese FH women had significantly higher levels of GHBP and androgens. They also discovered a significant correlation between GH and IGF-I serum levels and serum DHEAS levels in the combined group of patients and controls. The study concluded that the GH-IGF-I axis may be significantly involved in the hormonal and metabolic abnormalities associated with FH in non-obese women.
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