Absence of Prostatic Growth in a Large Cohort of Adult Female Patients with Congenital Adrenal Hyperplasia

In a study of 43 adult women with congenital adrenal hyperplasia, 11 were examined for prostatic tissue development. Despite androgen excess and genitourinary masculinization, magnetic resonance imaging and physical examinations revealed no definitive prostatic tissue in any of the patients. This finding contradicted rare case reports of prostatic growth and adenocarcinoma in similar patients, suggesting that notable prostatic growth was absent in this cohort. Understanding the factors influencing prostatic growth could help assess the risk of adverse outcomes in these women.