20 citations
,
October 2017 in “Clinical Endocrinology” This article reviews existing knowledge on postmenopausal hyperandrogenism and highlights diagnostic challenges, reporting no new clinical results.
February 2026 in “Zenodo (CERN European Organization for Nuclear Research)” In this cross-sectional study at a tertiary care hospital, researchers found a significant correlation between cutaneous manifestations like hirsutism and acne and biochemical hyperandrogenism levels in women with PCOS, suggesting these skin conditions can predict elevated androgen levels.
April 2020 in “Journal of the Endocrine Society” This case report details a post-menopausal woman with hirsutism and virilization due to rare Leydig cell tumors in both ovaries, underscoring the challenge of detecting such tumors with standard imaging.
May 2025 in “Journal of the ASEAN Federation of Endocrine Societies” This case report highlights the need to assess postmenopausal women with hirsutism for hyperandrogenism causes, as exemplified by a Leydig cell tumor coinciding with primary hyperparathyroidism.
April 2014 in “The FASEB Journal” This study examined 12 women with androgenetic alopecia and found that many had other symptoms linked to hyperandrogenism, suggesting the importance of further hormone level investigations.
99 citations
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August 2003 in “Fertility and Sterility” This paper discusses polycystic ovary syndrome with a focus on androgen excess as the primary symptom and notes that insulin resistance may contribute to it in many patients, but provides no new research findings.
4 citations
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December 2018 in “Case reports in endocrinology” This case study reported a postmenopausal woman with a testosterone-secreting ovarian tumor that was not detected through standard clinical or radiological examination but was found via biopsy.
This study found that in female androgenetic alopecia, androgen receptors are highly positive in affected areas, supporting their role as regulators of genetically predisposed hair follicles despite normal serum hormone levels.
October 2024 in “Journal of the Endocrine Society” This case study describes three young females with hirsutism who were diagnosed with different underlying conditions—late-onset congenital adrenal hyperplasia, idiopathic hirsutism, and polycystic ovary syndrome with ovarian thecosis—highlighting the need for reevaluation if initial treatments are ineffective.
14 citations
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January 2018 in “Advances in Clinical Chemistry” This review discusses the evaluation of hyperandrogenemia in women and hypogonadism in men across different life stages and presents biomarkers used for diagnosing male hypogonadism, reporting no new clinical results.
29 citations
,
January 1998 in “Dermatology” This research reports that many acne patients have elevated androgen levels, contributing to a cycle that may lead to polycystic ovarian disease and potentially sterility.
11 citations
,
February 2003 in “Baillière's best practice & research. Clinical obstetrics & gynaecology/Baillière's best practice and research in clinical obstetrics and gynaecology” This review discusses the relationship between acne, body hair, and androgenic stimulation in adolescent girls, emphasizing treatment decisions based on disease severity rather than endocrine findings.
54 citations
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November 1995 in “The Journal of Clinical Endocrinology & Metabolism” In this study, females with 5 alpha-reductase-2 deficiency exhibited decreased body hair, normal sebum production, and delayed menarche, suggesting a role for DHT in hair growth and menstrual function.
9 citations
,
February 2020 in “International Journal of Endocrinology” This study found that men with early-onset androgenetic alopecia and certain risk factors may have worse gonadal steroidogenesis and an increased likelihood of developing gonadal dysfunction, suggesting a male equivalent of polycystic ovarian syndrome.
6 citations
,
November 1980 in “Clinical Endocrinology” This study measured plasma testosterone glucosiduronate levels and found no overlap in those with hyperandrogenism compared to normal females, despite normal testosterone and dihydrotestosterone levels in half of the affected patients.
November 2023 in “JCEM Case Reports” In this case report, a 55-year-old postmenopausal woman was diagnosed with ovarian hyperthecosis as the cause of her hyperandrogenism after detailed hormonal and imaging investigations, which was successfully treated with bilateral salpingo-oophorectomy, leading to symptom improvement and normalized testosterone levels.
2 citations
,
January 2013 in “Elsevier eBooks” This chapter reviews the causes and underlying steroid pathways of hirsutism and virilization in women, detailing relevant conditions and laboratory assays without reporting new clinical results.
31 citations
,
January 1995 in “The American journal of medicine” This article reviews the role of 5α-reductase in cutaneous hyperandrogenism and the potential of 5α-reductase inhibitors and antiandrogens in treating conditions like hirsutism and male-pattern baldness, reporting no clinical results.
December 1976 in “PubMed” This review discusses the histology of pilo-sebaceous follicles, androgen receptors, and various treatments for hirsutism and acne in women, but it reports no new clinical results.
The text is about acne, excessive hair growth, and hair loss due to hormones.
July 1998 in “Annals of saudi medicine/Annals of Saudi medicine” This case report describes a misdiagnosed case of HAIR-AN syndrome with an unfortunate outcome, highlighting the challenges in distinguishing it from other hyperandrogenic conditions.
23 citations
,
June 1997 in “Baillière's clinical obstetrics and gynaecology” This article discusses various diagnostic categories and treatments for hyperandrogenism, with a focus on polycystic ovary syndrome and reports no new clinical findings, calling for specific treatments and lifestyle changes.
28 citations
,
April 2014 in “Hormones” This study found that increased serum A4A levels were associated with more severe polycystic ovary syndrome phenotypes and could be a useful marker for biochemical hyperandrogenemia.
17 citations
,
April 2010 in “Archives of Gynecology and Obstetrics” This study found that obese Taiwanese women had a lower incidence of acne than non-obese women, despite having higher serum testosterone levels.
October 1984 in “Kidney international” This case report describes a 23-year-old woman with a history of ambiguous genitalia and complex medical conditions, including a pelvic mass and hirsutism, observed from childhood to adulthood.
16 citations
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March 2000 in “Clinical Biochemistry” In this study, women with androgenic alopecia showed increased excretion of steroid metabolites and heightened 5α-reductase activity, suggesting these may contribute to the condition's hormonal abnormalities.
11 citations
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August 2019 in “PubMed” This review discusses the causes, evaluation, and treatment options for hirsutism in women, but reports no new clinical results.
September 2024 in “Journal of the American Academy of Dermatology” In this prospective study, researchers observed that early-onset androgenetic alopecia may predispose young male patients to metabolic syndrome, as significant differences in metabolic profiles were found between these patients and age-matched controls.
April 2019 in “Journal of the Endocrine Society” This case report described a 62-year-old postmenopausal woman with hirsutism whose symptoms improved after a hysterectomy and bilateral oophorectomy, revealing bilateral ovarian hyperthecosis.
42 citations
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July 2015 in “Journal of The American Academy of Dermatology” This review discusses diagnostic and treatment considerations for women with cutaneous hyperandrogenism, noting therapeutic options are more effective for hirsutism and acne than for androgenetic alopecia, but reports no new clinical results.