3 citations
,
November 2005 in “Women's health” This narrative review discusses various causes and treatments of hirsutism in women, emphasizing the importance of identifying androgen-secreting tumors, but does not present new study results.
21 citations
,
May 2001 in “PubMed” This paper reviews the significance of androgen hormones in hair and skin conditions like alopecia, hirsutism, and acne, and reports no new clinical findings.
January 2019 in “Paëmi Sino” This study found that acne and androgenic alopecia were prevalent in women with "true" keloids, suggesting hormonal imbalances may contribute to keloid formation.
1 citations
,
January 2007 in “Humana Press eBooks” This review discusses the causes and treatments of hirsutism in women and reports no clinical results; it emphasizes the importance of identifying androgen-secreting tumors that require distinct therapy.
24 citations
,
March 2017 in “Archives of Gynecology and Obstetrics” The study found that women with hyperandrogenic PCOS have higher levels of AKT1 and AKT2 proteins in their cells, which may lead to cell dysfunction.
10 citations
,
March 2024 in “Endocrine Reviews” In this retrospective review, the author discusses key discoveries in understanding androgen excess disorders like PCOS, focusing on genetic and molecular insights gained from 1965 to 2015.
January 2015 in “International Journal of Research in Medical Sciences” This case report is the first to associate HAIR-AN syndrome with polycystic ovaries, Hashimoto’s thyroiditis, and several metabolic conditions in a 21-year-old woman, emphasizing early diagnosis and management.
30 citations
,
August 2019 in “Medical Sciences” This review summarizes evidence suggesting that excess androgens play a key role in the origins of polycystic ovary syndrome, highlighting opportunities for developing targeted treatments.
5 citations
,
June 2020 in “Journal of Endocrinological Investigation” The study observed that women with congenital adrenal hyperplasia experience more impaired sexual functions and are more often homosexually or bisexually oriented than those with polycystic ovary syndrome.
May 2024 in “Research Square (Research Square)” In this retrospective study from Jiangsu Province Hospital, researchers reported a high prevalence of pediatric androgenetic alopecia in patients under 18, often associated with hormonal imbalances and comorbid conditions, emphasizing the need for individualized treatment plans that prioritize addressing hormonal disorders and comorbidities.
May 2006 in “Women's Health Medicine” This review examines the causes, assessment, and treatments of hirsutism and highlights the need for future research in managing this condition but presents no new research findings.
39 citations
,
May 2011 in “European Journal of Clinical Investigation” This review discusses the various causes of hirsutism other than PCOS, emphasizing the importance of distinguishing potentially life-threatening conditions like androgen-secreting tumors from more benign causes; it reports no new clinical findings.
May 2025 in “International Journal of Nursing Education and Research” In this qualitative study, researchers explored the impact of hyperandrogenism on young female adults, identifying themes including appearance-related challenges, emotional distress, social support issues, and insufficient knowledge, which all affect well-being.
4 citations
,
January 2000 in “PubMed” In this study, researchers found that young men with premature androgenetic alopecia had a hormonal profile similar to the pattern seen in women with polycystic ovary syndrome, suggesting a possible genetic link.
1 citations
,
December 2022 in “Gynecological Endocrinology” This study found that among women with PCOS, higher HOMA-IR levels were associated with acanthosis nigricans, and increased DHEA-SO4, FAI, and FI values were linked to hirsutism.
March 2025 in “Journal of Pediatric Endocrinology and Metabolism” This study found that total testosterone, DHEA-S, and free androgen index may help distinguish menstrual irregularities from increased risk of polycystic ovary syndrome in adolescents.
36 citations
,
May 2011 in “The Journal of Clinical Endocrinology & Metabolism” Treatment with a hormone agonist can reduce excess male hormones in postmenopausal women without surgery.
13 citations
,
October 2002 in “Journal of Biochemical and Biophysical Methods” This study found that men with androgenic alopecia had significantly higher levels of certain urinary steroid metabolites, suggesting increased 5 alpha-reductase activity and possible mild hyperadrenal activity.
3 citations
,
February 2002 in “The American journal of psychiatry” This report describes a potential association between HAIR-AN syndrome and the onset of manic symptoms in a patient after discontinuing oral contraceptives, though this relationship requires further investigation.
April 1999 in “Therapeutische Umschau” This review discusses androgenic alopecia and related hair disorders, focusing on their pathogenesis and treatment strategies, and reports no new clinical findings.
1 citations
,
January 2017 in “Tohoku journal of experimental medicine” This study reports the first case of ovarian mature cystic teratoma linked to clinical virilization due to ectopic testosterone production, possibly from overexpression of the enzyme HSD17B5.
10 citations
,
November 2024 in “Diagnostics” This review discusses the role of elevated androgens in the skin-related symptoms of polycystic ovary syndrome, such as acne and hirsutism, and provides insights into the mechanisms behind these manifestations to inform effective treatment strategies.
1 citations
,
September 2020 in “Endocrinology, Diabetes & Metabolism Case Reports” This case report describes a woman with hypertension, alopecia, and other symptoms, revealing that her condition was due to ovarian hyperthecosis, highlighting the overlap of adrenal and ovarian disorders.
In this report, a 22-year-old woman with congenital adrenal hyperplasia due to 21-hydroxylase deficiency underwent treatment with hydrocortisone and spironolactone, followed by feminization surgery, which subsequently led to the development of secondary sexual characteristics and regular menstruation.
28 citations
,
July 2017 in “Journal of Endocrinological Investigation” This study suggests that early onset androgenetic alopecia in men may indicate a male PCOS equivalent, possibly leading to higher risks of metabolic and cardiovascular disorders later in life.
4 citations
,
December 2012 in “Arquivos Brasileiros De Endocrinologia E Metabologia” A postmenopausal woman's masculine symptoms improved after surgery for a hormone-producing ovarian tumor.
3 citations
,
May 2023 in “Endocrine Abstracts” This study identified three subgroups of women with PCOS with distinct androgen profiles, finding that the subgroup with adrenal-derived androgen excess had the highest insulin resistance and rates of hirsutism and hair loss.
1 citations
,
December 1997 in “Journal of The European Academy of Dermatology and Venereology” In this study, 85.9% of 120 hirsute Saudi women exhibited elevated androgen levels, suggesting the need for a comprehensive hormonal evaluation to identify underlying causes of hirsutism.
18 citations
,
January 1985 in “Acta Obstetricia Et Gynecologica Scandinavica” In this study of hirsute women, researchers found that correlations between hirsutism and hyperandrogenism were observed only in patients with a low LH/FSH ratio.
6 citations
,
April 1989 in “The American Journal of the Medical Sciences” In this case study, prolonged selective suppression of adrenal androgens by glucocorticoids was most likely attributed to the observed loss of pubic and axillary hair in a woman post-bilateral oophorectomy.