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This review explores how recombinant protein hydrogels, employing molecular engineering and crosslinking strategies, offer advanced applications in regenerative medicine by mimicking extracellular matrix dynamics and providing enhanced mechanical, environmental, and biological properties.

This study found that encapsulating dermal papilla spheroids in alginate hydrogel with extracellular matrix proteins increased alkaline phosphatase activity, suggesting an enhanced manipulation of dermal papilla activity.

This study introduces a new device for measuring changes in hair stiffness and lubricity, which can help predict the effects of various hair treatments.

This study found that the pH-sensitive hydrogel HECHA13, containing isoliquiritigenin, effectively inhibited the growth of Propionibacterium acnes and showed promise for transdermal delivery in acne treatment.

This study developed HA-gel-dex hydrogels with enhanced ECM-like properties and functionality, showing promise for 3D bioprinting, tissue repair, and as wound dressings due to improved cell interaction, cytocompatibility, antimicrobial synergy, and wound healing in mice compared to traditional ECM bio-inks.

This review details how hydrogel composites play crucial roles in regenerative medicine, tissue engineering, and drug delivery systems, highlighting innovations in these applications and addressing challenges like bioactivity, biomechanical compatibility, and controlled drug release.

This review discusses transdermal drug delivery using hydrogel-forming microneedles and highlights their potential and challenges for clinical application, but it reports no new clinical findings.

This study proposes using superhydrophobic surfaces to reduce protein fouling and enable self-cleaning in microfluidic devices, detailing preparation and quantification methods for these coatings.

This review summarizes recent advancements in three-dimensional bioprinting technology and hydrogel bioinks, highlighting their applications in tissue engineering, but reports no new experimental results.

In a study on wound healing, researchers described injectable POEGMA‐DA hydrogels as a promising non-toxic alternative to traditional wound closure methods, showing effective tissue adhesion and enhanced regeneration of skin structures in a mouse model without significant inflammation.

The hydrogel helps heal wounds without scars by releasing two drugs gradually.

This study highlights the importance of understanding the rheological properties of hyaluronic acid fillers, including viscosity, cross-linking, and concentration, to optimize their use in addressing facial aging by maximizing clinical effects.

This literature review highlights recent findings that cosmetic procedures like face lifts and hyaluronic acid fillers can occasionally lead to hair loss as a rare complication.

This article describes a modified follicular unit extraction technique using a reverse rake scalp elevator, which may reduce follicular transection rates in hair transplantation from the lower occipital donor region.

This article discusses the introduction of human recombinant hyaluronidase in hair restoration surgery and presents no new clinical results.

This review examines the design strategies for creating conductive hydrogels with adjustable properties for various biomedical applications, highlighting their potential for supporting cell growth, wound healing, drug delivery, tissue regeneration, and biosensing.

In this study, a hydrogel loaded with SHP099 was shown to improve wound healing by targeting different cell types during various stages of the healing process.

This review outlines guidelines for designing Janus hydrogel bioadhesives, highlighting their potential to enhance clinical applications in tissue repair and regenerative medicine by mimicking natural biological barriers, although challenges remain in optimizing their asymmetric surface designs.

Using a patient's own tissue for browlifting can improve both the position and fullness of the brow for a longer-lasting rejuvenation.

This study found that hyaluronic acid increased the size and cell proliferation of mixed aggregates in a 3D culture model, indicating its role in human hair follicle germ-like structure formation without enhancing dermal papilla cell markers.

This study observed that injecting minimally cross-linked hyaluronic acid with PDO smooth threads in female patients with dry, cracked lips led to significant improvements in lip texture, elasticity, and reduced fissure depth, effects that lasted up to nine months with additional booster injections.

This review highlights recent advances in hydrogel-based wound healing, noting that diverse hydrogel designs enhance healing and suggest potential for clinical translation, albeit with a need for more research on human applications.

This study found that a new formulation using short chain esters and ethanol can selectively deliver hydrogen peroxide to hair follicles during epilation, causing follicular damage without affecting epidermal keratinocytes.

This review examines hydrogel microneedles for transdermal drug delivery, discussing their applications and challenges but reports no new clinical results.

Endoscopic forehead and brow lifting safely and consistently improves aged eyebrows, but may have complications.

This study demonstrated that OSA hydrogels enhanced the stability and retention of dermal papilla-derived extracellular vesicles, which significantly improved hair regeneration in both cultured human hair and a mouse depilation model.

This study presents a novel hydrogel scaffold made from tilapia collagen, which when activated by ultrasound, reprograms macrophages to promote wound healing, enhance angiogenesis, and stimulate hair follicle regeneration, offering a potential new method for treating inflammatory wounds.

This review explores how combining extracellular vesicles with hydrogels and utilizing 3D bioprinting technologies creates innovative composite systems for wound healing, offering advanced mechanical and biological support, while addressing challenges like degradation and regulatory issues in clinical applications.