TLDR Researchers developed a new method to deliver molecules to hair follicles to manage hair growth without damaging surrounding skin.
In 2019, researchers developed a new formulation designed to deliver active molecules specifically to the hair follicle for promoting or inhibiting hair growth, while avoiding delivery to interfollicular epidermis. The method involved using a combination of short chain esters and ethanol to deliver an aqueous solution of hydrogen peroxide to human hair follicles from normal skin biopsies. The application, which lasted less than a minute, did not affect the structure and viability of epidermal keratinocytes but caused structural follicular damage and diffuse apoptosis in the outer root sheath. The researchers suggested that this method could be a promising approach to the treatment of hair growth disorders due to its selectivity, ease of application, and the known safety of the ingredients used.
January 2022 in “Journal of St. Marianna University” Substances from human hair cells can affect hair loss-related genes, potentially leading to new treatments for baldness.
95 citations
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July 2006 in “British Journal of Dermatology” This study investigated the expression of vitamin D receptors (VDR) in hair follicles during the murine hair cycle, using C57 BL-6 mice. VDR expression was detected in both outer root sheath keratinocytes and dermal papilla cells, with stronger immunoreactivity observed during the anagen IV-VI and catagen phases compared to telogen and anagen I-III. These findings suggested that VDR expression varied with the hair cycle, indicating a potential role for 1,25-dihydroxyvitamin D3 in hair follicle biology and suggesting that certain follicular cell populations might have hair cycle-dependent sensitivity to this hormone.
10 citations
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October 2000 in “PubMed” E6/E7 oncogenes in hair follicles cause continuous hair growth by skipping the resting phase.
27 citations
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October 1998 in “Differentiation” 154 citations
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October 1996 in “Proceedings of the National Academy of Sciences of the United States of America” Estrogen affects hair growth and skin cell multiplication.
94 citations
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February 1994 in “The journal of investigative dermatology/Journal of investigative dermatology” EGF makes hair follicles grow longer but stops hair production.
