Targeted Hair Follicle Delivery of Hydrophilic Molecules

September 2019 in “ Journal of Investigative Dermatology ”

Sreekanth Vootukuri Reddy, Michael P. Philpott, Giuseppe Trigiante

hair follicle hydrophilic molecules hair growth short chain esters ethanol hydrogen peroxide epidermal keratinocytes outer root sheath apoptosis hair growth disorders skin cells cell death

TLDR Researchers developed a new method to deliver molecules to hair follicles to manage hair growth without damaging surrounding skin.

In 2019, researchers developed a new formulation designed to deliver active molecules specifically to the hair follicle for promoting or inhibiting hair growth, while avoiding delivery to interfollicular epidermis. The method involved using a combination of short chain esters and ethanol to deliver an aqueous solution of hydrogen peroxide to human hair follicles from normal skin biopsies. The application, which lasted less than a minute, did not affect the structure and viability of epidermal keratinocytes but caused structural follicular damage and diffuse apoptosis in the outer root sheath. The researchers suggested that this method could be a promising approach to the treatment of hair growth disorders due to its selectivity, ease of application, and the known safety of the ingredients used.

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