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New findings explain how genetic changes, body clocks, and certain molecules affect tissue response to stress hormones.

A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.

Mutations in certain receptors can cause diseases and offer new treatment options.

Chrousos Syndrome is caused by mutations that make the body less sensitive to glucocorticoids, leading to various symptoms and requiring high-dose treatment.

Genetic defects in the glucocorticoid receptor gene can cause conditions with abnormal sensitivity to stress hormones, and other factors may also affect this sensitivity.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

Mutations in the glucocorticoid receptor gene cause reduced sensitivity to glucocorticoids and may lead to poor response to treatment.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

Mutations in the NR3C1 gene cause a rare condition that affects hormone signaling and can lead to various symptoms, with dexamethasone as a treatment option.

Certain defective glucocorticoid receptor mutants move faster inside cell nuclei and work less effectively.

The N363S gene variant does not cause higher adrenal androgen levels in women with polycystic ovary syndrome.

Glucocorticoids and sex hormones affect skin health, with potential for targeted treatments to minimize side effects and treat skin conditions.

Scientists have developed a new method to detect steroid abuse in athletes using cell-based tests, which could be the future of anti-doping methods.

Hair follicle bulge cells don't help skin regrow after glucocorticoid damage; interfollicular epidermis cells do.

A new gene mutation causes female pseudohermaphroditism due to glucocorticoid resistance.

The review suggests thorough evaluation and genetic testing for proper diagnosis and treatment of Chrousos syndrome.

Inhibitors of 11β-HSD1 show potential for treating type 2 diabetes but require more testing for safety and effectiveness.

Different types of androgens bind differently to two receptors, AR1 and AR2, in Atlantic croaker's brain and ovarian tissues, suggesting these receptors may control different androgen actions in fish.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Treating non-classic congenital adrenal hyperplasia is complex because the benefits of hormone treatment must be weighed against potential health risks.

The document concludes that mouse models are crucial for studying hair biology and that all mutant mice may have hair growth abnormalities that require detailed analysis to identify.

Genetic mutations can affect female sexual development, requiring personalized medical care.

Combination pharmacotherapy is generally more effective for treating keloids and hypertrophic scars.

Dexamethasone increases the activity of androgen receptors in human skin cells, which may link it to certain types of hair loss.

Dexamethasone affects hair growth by altering levels of proteins that either promote or inhibit hair follicle growth.

Blocking the mineralocorticoid receptor can help treat skin thinning caused by steroids.

Estrogens generally inhibit hair growth and improve skin quality, but their exact effects on hair follicles are complex and not fully understood.

Local skin glucocorticoid production is crucial for healthy skin, and its disruption can lead to skin diseases.

Glucocorticoids are powerful anti-inflammatory drugs that must be used carefully to avoid serious side effects.

Ganoderma lucidum extract may help treat stress-related hair loss.