Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study reports the cloning and sequencing of two type II hair-specific keratin genes, ghHb1 and ghHb6, located on chromosome 12q13, which are expressed during hair growth.

This review highlights REV7's crucial roles in maintaining genome stability, its implication in several cancers, and its association with poor prognoses and treatment resistance, while also noting that REV7 suppression may improve chemotherapy sensitivity.

This study found that the development of Merkel cell carcinoma from hair follicles in mice can be driven by in vivo reprogramming with ATOH1 and relies on p53 loss for progression.

This report describes a rare case of porokeratotic eccrine ostial and dermal duct nevus in a 64-year-old woman, successfully treated with CO₂ laser, highlighting its potential occurrence in older adults.

This study found that skin is a significant site for estrogen production in mice, impacting both hair cycle regulation and sensitivity to chemical carcinogenesis.

This study found that the EpiLight Hair Removal System achieved approximately 60% hair removal after 12 weeks following a single treatment, indicating effectiveness and safety for long-term hair reduction.

This study found that variations in the IL16 gene, specifically SNPs rs17875491 and rs11073001, may be associated with increased risk and phenotype expression of alopecia areata in the Korean population.

This study found that the SVpgC2a keratinocyte cell line, used as a model for dysplastic epithelium, showed increased apoptosis, proliferation, and aberrant keratin expression compared to normal keratinocytes from buccal mucosa.

This study found that super-enhancers play a crucial role in driving malignant progression in squamous cell carcinoma stem cells through a regulatory network involving ETS2 transcription factors, highlighting the potential link between high ETS2 levels and poor patient outcomes in head and neck cancers.

Photodynamic therapy may not work for erythroplasia of Queyrat and could lead to invasive squamous cell carcinoma.

This study found that overexpression of ornithine decarboxylase and activated Ha-ras together led to a high rate of tumor development in a mouse model without additional carcinogens.

This article discusses Human Metapneumovirus (HMPV) and highlights the need for continued research, noting that while supportive treatments exist, no vaccines or specific therapies are currently available.

This study developed a mouse model lacking keratin 16 to replicate palmoplantar lesions, which may help uncover the molecular mechanisms driving these lesions in pachyonychia congenita and focal non-epidermolytic palmoplantar keratoderma.

This study found that patients with the MITF p.E318K variant are more likely to develop multiple primary melanomas and dysplastic nevi with uncommon dermoscopic patterns compared to non-carriers.

This review reports two new cases of porokeratotic eccrine and hair follicle nevus and analyzes all known cases in the Spanish and English literature, suggesting a link to a GJB2 gene mutation.

This study identified a mutation in the KRTHB6 gene in two monilethrix families of Indian origin, linking specific genetic variations to different severities of hair defects within the families.

This study documented distinct expression patterns of stem cell markers LGR5 and LGR6 in various human skin tumors, highlighting differences in their potential roles and contributions to tumor development.

In this study, researchers reported that specific immunoreactivity patterns observed in hair follicle stem cell markers suggest different origins for trichilemmoma, basal cell carcinoma, and squamous cell carcinoma in human skin tissues.

This study reports the first case of ovarian mature cystic teratoma linked to clinical virilization due to ectopic testosterone production, possibly from overexpression of the enzyme HSD17B5.

This study found that 1550-nm Er:Glass fractional laser treatment significantly increased hair density and shaft diameter in patients with androgenetic alopecia, though the mechanism may not involve Wnt10A or IGF-1 expression.

This article discusses the highlights and key topics from the 17th Congress of the European Academy of Dermatology and Venereology but reports no new results.

This study found that ectodermal precursor cells derived from human induced pluripotent stem cells may enhance hair follicle morphogenesis through improved epithelial-mesenchymal interactions when cocultured with dermal cells.

This study found that the heat shock cognate protein Hsc70 was differentially expressed by dihydrotestosterone treatment in SV40-transformed dermal papilla cells, suggesting its involvement in androgen action on these cells.

This study reported that an HS-associated NCSTN mutation in iPSC-derived skin organoids led to altered hair follicle stem cell differentiation and increased expression of proteins linked to HS inflammation.

This study identified a novel mutation, R430Q in the KRT86 gene, in a Han family with monilethrix, which may contribute to the disease's pathogenic mechanism.

This article reports on a partial regrowth of scalp hair in a patient treated with extracorporeal photochemotherapy and interferon α 2a, but provides no new clinical outcomes.

This article discusses eruptive vellus hair cysts, detailing their appearance, distribution, histology, and potential spontaneous resolution, but reports no new clinical findings on treatment.

In this study, Swedish men carrying the AR haplotype H2 were found to have a significantly lower risk of prostate cancer compared to those with the more common H1 variant.

The study found that silencing the gene p16INK4a in dermal papilla cells promotes their growth and aggregative behavior, suggesting a potential therapeutic target for androgenetic alopecia.