TLDR Porokeratotic eccrine and hair follicle nevus is a very rare skin disorder possibly caused by a GJB2 gene mutation.
Porokeratotic eccrine and hair follicle nevus is an extremely rare disorder of keratinization involving eccrine glands and hair follicles, with only 9 cases previously reported. In 2009, the term porokeratotic anexial ostial nevus was introduced to include this condition and a related, more common disorder without follicular involvement, known as porokeratotic eccrine ostial and dermal duct nevus. Recent research suggested that both conditions might be caused by a mutation in the GJB2 gene, which is also linked to KID syndrome. This report presented 2 new cases and reviewed the existing literature in Spanish and English.
23 citations,
September 2014 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” Laser treatments are the most effective for porokeratotic adnexal ostial nevus.
17 citations,
September 2010 in “Pediatric dermatology” A 15-year-old with KID syndrome developed a rare skin condition called PEHFN.
60 citations,
August 2009 in “Journal of the American Academy of Dermatology” The term "porokeratotic adnexal ostial nevus" is proposed to unify overlapping skin conditions involving eccrine and hair follicles.
October 2022 in “Experimental Dermatology” New technologies show promise for better hair regeneration and treatments.
April 2017 in “Journal of Investigative Dermatology” Dermal Wnt/β-catenin signaling is important for the proper size and development of hair follicles.
April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” Researchers developed a method to grow human hair follicles using 3D-printed skin models and modified cells.
66 citations,
August 2001 in “Experimental Dermatology” Human hair follicle cells can grow hair when put into mouse skin if they stay in contact with mouse cells.
