17 citations,
August 2019 in “The journal of immunology/The Journal of immunology” A specific DNA region is crucial for Foxn1 gene expression in thymus cells but not in hair follicles.
9 citations,
July 2016 in “Stem cells” Overexpression of sPLA2-IIA in mouse skin reduces hair stem cells and increases cell differentiation through JNK/c-Jun pathway activation.
6 citations,
August 2022 in “Science immunology” Foxn1 gene regulation is crucial for thymus development but not for hair growth.
5 citations,
September 2011 in “Cell stem cell” Epigenetic changes are crucial for hair follicle stem cells to function properly.
4 citations,
August 2022 in “International Journal of Molecular Sciences” Human foreskin does not show aging or reduced cell growth after radiation, and H2A.J is not a good marker for radiation-induced aging.
4 citations,
November 2020 in “BMC Dermatology” Researchers identified genes in scalp hair follicles that may affect hair traits and hair loss.
4 citations,
August 2020 in “Journal of proteomics” Hair protein composition is similar across different races and shapes.
4 citations,
August 2018 in “Journal of cellular biochemistry” Acid inside cells speeds up aging and turns on aging signs in mice.
Delta-opioid receptors affect skin cell circadian rhythms, possibly impacting wound healing and cancer.
January 2024 in “Theranostics” HDAC6 helps keep ovarian follicles dormant, extending female fertility.
November 2023 in “Magna Scientia Advanced Research and Reviews” Trazodone might help reverse post finasteride syndrome.
May 2023 in “Journal of Investigative Dermatology” LSD1 is essential for healthy skin development and creating the skin's protective barrier.
October 2017 in “Journal of Investigative Dermatology” Hair follicle cells change their DNA packaging during growth cycles and when grown in the lab.
September 2015 in “Free Radical Biology and Medicine” The study suggests that higher levels of SIRT1 and SIRT2 may improve overall cell health and aging processes.
Both changes in genes and environmental factors like diet and toxins can significantly affect the growth of skin appendages like hair, but how these factors interact is still unclear.
August 2012 in “Nature Cell Biology” Hair grows when stem cell offspring in the follicle base proliferate, influenced by the dermal papilla.
April 2012 in “Encyclopedia of Life Sciences” Different genes are linked to various types of hair loss.
38 citations,
July 2016 in “Experimental Dermatology” The document concludes that understanding hair follicle cell cycles is crucial for hair growth and alopecia research, and recommends specific techniques and future research directions.
4 citations,
September 2020 in “Cell division” XMU-MP-1 stops cell growth in a human mini-organ and reduces the effectiveness of the chemotherapy drug paclitaxel.
July 2020 in “The journal of investigative dermatology/Journal of investigative dermatology” Scientists found new and known long non-coding RNAs in mouse hair follicle stem cells that may be important for stem cell function and could be targets for cancer treatment.
3 citations,
October 2019 in “EMBO molecular medicine” Targeting NCoR1 can help treat heart enlargement and dysfunction.
49 citations,
March 2017 in “PubMed” Enhancers and super-enhancers are key in controlling specific gene activity and can play a role in cancer development.
November 2023 in “Circulation” Minoxidil can cause a rare but serious condition that leads to fluid buildup around the heart and drug-induced lupus.
September 2015 in “Free Radical Biology and Medicine” Some treatments can improve skin's defense against damage, but overuse may cause other skin problems.
February 2011 in “Expert Review of Dermatology” Researchers found potential new targets for treating melanoma and nonmelanoma skin cancers, and identified a possible cause and treatment for male pattern baldness and eczema.
October 2012 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” Scientists used a special imaging technique to observe that hair follicle regeneration involves cell division and structural changes, mostly in the lower part of the follicle, and that the dermal papilla at the base is crucial for regrowth.
May 2019 in “Journal of Investigative Dermatology” Women with scarring alopecia are less likely to have used hormone replacement therapy or oral contraceptives compared to those with female pattern hair loss.
May 2019 in “Journal of Investigative Dermatology” Calcium signals and SHH guide the direction of feather growth in chicken skin.
May 2019 in “Journal of Investigative Dermatology” Eating grape powder may reduce the severity of skin allergy symptoms.
8 citations,
March 2014 in “Experimental Dermatology” Light and temperature affect the daily skin function rhythms in hairless rats, with temperature influencing water loss but not skin hydration.