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A special gene region controls the re-emergence of a primitive wool type in Merino sheep, improving their wool yield and adaptability.

SARMs may be an effective treatment for a certain type of breast cancer by blocking cancer growth and spread.

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Liposomes could improve how skin care products work but are costly and not very stable.

Mutations in Gasdermin A3 cause skin inflammation and hair loss by disrupting mitochondria.

AIRE-deficient rats developed severe autoimmune disease similar to APECED, useful for testing treatments.

Steroid Sulfatase inhibitors show promise in treating hormone-dependent disorders like cancers, hair loss, and acne, with 667COUMATE being a potential candidate for breast cancer treatment trials.

A new mutation in the LIPH gene was found to cause a rare hair disorder in a Japanese boy.

Astrotactin proteins are important for brain and skin development and are linked to several neurodevelopmental disorders.

Two new compounds were found to effectively reduce hair growth in mice.

New probes were created to effectively measure specific enzymes involved in fat metabolism, which could help develop new drugs.

Activating TLR5 in the gut can extend lifespan and improve health in aged mice.

MOF controls key genes for skin development by regulating mitochondrial and ciliary functions.

Genetic mutations can affect female sexual development, requiring personalized medical care.

Certain mutations in the H6PD gene cause Cortisone Reductase Deficiency by affecting hormone production.

Chemokine signaling is important for hair development.

FGF9 controls which receptors it binds to through a process where two FGF9 molecules join, and changes in FGF9 can lead to incorrect receptor activation.

A specific gene change plus an additional mutation in the same gene cause hereditary trichilemmal cysts.

Wnt activation shows promise for regenerative medicine but requires selective targeting to minimize risks like cancer.

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

BeauTop improves hair growth in androgenetic alopecia patients.

Researchers identified genes in scalp hair follicles that may affect hair traits and hair loss.

The document reports findings on genetic research, including ethical concerns about genome editing, improved diagnosis of mitochondrial mutations, solving inherited eye diseases, confirming gene roles in epilepsy, linking a gene to aneurysms, and identifying genes associated with age-related macular degeneration.

Blocking glucocorticoid receptors improves glucose metabolism in a PCOS mouse model.

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

Let-7b helps alpaca hair grow by reducing TGFβR I protein.

The document concludes that MGRN1 affects mouse fur color by interfering with a receptor's signaling, but its full role in the body is still unknown.