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Artificial sebum L closely mimics human sebum for drug delivery research.

Certain adrenal hormones can strongly stimulate oil gland growth in hamster skin, similar to male hormones.

Pfizer found that pantolactam-based compounds can reduce sebum (skin oil) production when applied topically.

Hair follicles could be used to deliver drugs effectively, with the right understanding and methods.

Nanoparticles effectively deliver water-insoluble drugs to hair follicles, stimulating hair growth without irritating the skin.

A new compound was created in 2010 that can control oil production when applied to the skin, and its effects are completely reversible after two weeks.

Diphenyl ethers can potentially reduce excess oil production when applied on the skin, helping treat conditions like acne.

Topical finasteride and flutamide reduce gland size and enzyme activity, with flutamide being more potent, potentially treating acne, seborrhea, hirsutism, and androgenic alopecia.

Different tea tree oil mixtures absorb into hair follicles at varying levels, with microemulsion being the most effective.

A compound made by Pfizer can potentially stimulate hair growth and reduce oil production, making it a good candidate for topical use.

The compound (1R,2S)-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile can stimulate hair growth and reduce oil production when applied topically.

The compounds tested could potentially treat hair loss and alopecia.

Hair follicles may soon be used more for targeted and systemic drug delivery.

Minoxidil and finasteride treat hair loss; more research needed for other options.

Hair follicles could be used for targeted drug delivery, with liposomal systems showing promise for this method.

Liposomes and niosomes improve finasteride delivery for hair loss treatment.

Antiandrogens affect androgen-dependent body functions and are used for various medical conditions, with some risks like fetus feminization, but new forms like 17α-propylmesterolone show promise for acne without systemic effects.

Chemicals called 4-(alkylthio)- and 4-(arylthio)-benzonitrile derivatives can potentially reduce oil production on skin, which could help treat conditions like acne and hair loss.

Scientists made a chemical (compound 4e) that can be applied on skin to reduce oil production, which can help with acne, but it might cause skin sensitivity to light.

New liposomal formulations may improve delivery of treatments to hair follicles, potentially helping with hair loss.

Medium lipophilic substances penetrate skin best, and adding ethanol can increase delivery to hair follicles.

Methyl caprate greatly increases drug absorption through the skin and is better than other enhancers.

Hair follicles help absorb and store topical compounds, aiding targeted drug delivery.

Liposomes improve drug delivery and reduce skin irritation in dermatology.

Anti-acne medications may work by reducing the activity of a protein involved in acne development.

Liposomes can safely and effectively deliver substances to mouse hair follicles, potentially useful for human hair treatments.

Liposomes can make the antiandrogen RU 58841 more effective for skin application by reducing absorption, increasing skin retention, and targeting sebaceous structures.

Spironolactone works well for acne and hirsutism, isotretinoin is very effective for acne and may have antiandrogenic effects, and 5 alpha-reductase inhibitors should be considered antiandrogens.

Cyproterone acetate is used to treat conditions like prostate cancer, early puberty, excessive sexual drive, and female androgenization by affecting androgen functions and suppressing certain hormones.

Liposomal systems show promise for delivering drugs through the skin but face challenges like high costs and stability issues.