11 citations
,
January 2005 in “Brazilian Journal of Medical and Biological Research” This study found no qualitative skin differences during development between mutant hairless USP mice and BALB/c mice, except for enlarged cysts in the hairless strain.
24 citations
,
January 2003 in “Drug Delivery” This study found that only minoxidil encapsulated in cationic vesicles significantly promoted hair growth in mice, likely due to its higher retention on the skin.
6 citations
,
July 2009 in “Biomolecules & therapeutics” This study found that combining MSM with MAP significantly enhanced hair growth in mice, comparable to or better than minoxidil, due to increased intradermal retention of MAP.
21 citations
,
September 2008 in “Magnetic Resonance Imaging” This study utilized magnetic resonance imaging to noninvasively visualize and differentiate skin structures in rat skin, finding a significant correlation between MRI data and histological areas.
30 citations
,
December 2001 in “Experimental dermatology” This study found that gonadal steroid hormones influence alopecia areata in C3H/HeJ mice, with estradiol promoting progression and dihydrotestosterone conferring resistance to disease onset.
January 2026 in “Industrial Crops and Products” In this study, oral administration of ginsenoside Rf from Panax ginseng promoted hair regrowth and increased hair thickness in a mouse model of androgenetic alopecia by enhancing androgen receptor degradation, highlighting its potential for cosmetic and functional food applications.
July 2025 in “Pharmaceuticals” In this study, chitosan nanoparticles loaded with phenobarbital were the most effective in promoting hair regrowth and quality in a mouse model of chemotherapy-induced alopecia, suggesting potential for preventing hair loss in cancer patients.
61 citations
,
June 2022 in “Journal of Controlled Release” This review discusses the advantages, applications, and current trends of dissolving microneedles for drug delivery across various therapeutic areas and reports no new clinical results.
32 citations
,
March 2013 in “Journal of Pharmaceutical Sciences” This study observed that iontophoresis significantly improved the delivery of minoxidil sulfate to hair follicles compared to passive methods, suggesting potential benefits for alopecia treatment.
3 citations
,
September 1989 in “Journal of Investigative Dermatology” This study found that methyl nonanoate and methyl caprate significantly enhanced the skin penetration of minoxidil compared to solutions with other common enhancers like Azone, DMSO, or DEET.
22 citations
,
November 2018 in “Brazilian Journal of Pharmaceutical Sciences” This review discusses iontophoresis, low-frequency ultrasound, and microneedles for enhancing topical drug delivery in dermatological treatments and reports no clinical results; it emphasizes their mechanisms and potential uses.
32 citations
,
June 2017 in “Journal of Pharmaceutical Sciences” This study found that coating liquid crystalline nanoparticles with chitosan significantly enhanced the skin permeation of 5α-reductase inhibitors, suggesting a promising strategy for improving topical delivery in androgenetic alopecia treatment.
14 citations
,
January 2025 in “AAPS PharmSciTech” This review highlights the promising potential of microemulsions and nanoemulsions in (trans)dermal drug delivery, noting a gap in understanding their distinct mechanisms and composition-related effects on skin permeability, while emphasizing the limited clarity on mesostructures and cosolvent impacts.
5 citations
,
August 2018 This paper highlights the growing scientific interest in plant extracts for cosmetics due to their potential benefits, including antioxidant, antimicrobial, and protective properties, while emphasizing the need for quality and safety assessment to mitigate possible adverse reactions.
1 citations
,
March 2024 in “Signal transduction and targeted therapy” In this review, researchers explored the multifaceted role of NF-κB signaling in various biological processes and diseases, including its interactions with other pathways, and discussed possible therapeutic approaches targeting this pathway for treating conditions like cancer, autoimmune disorders, and COVID-19.
29 citations
,
March 1983 in “Journal of The American Academy of Dermatology” This article reviews existing and emerging treatments for psoriasis, focusing on therapy modifications due to scientific advancements, but it does not report new clinical results.
4 citations
,
March 2013 in “InTech eBooks” Confocal Laser Scanning Microscopy (CLSM) is a useful tool for studying how drugs interact with skin and diagnosing skin disorders, despite some limitations.
202 citations
,
June 2005 in “Aaps Pharmscitech” This review discusses the potential of lecithin organogels for improving topical drug delivery and presents no new experimental results; the authors highlight their stability and low skin irritancy as advantages.
58 citations
,
December 2012 in “Aaps Pharmscitech” This study suggests that finasteride-loaded liquid crystalline nanoparticles could be a viable alternative to oral administration for treating androgenetic alopecia due to their controlled release and skin permeation properties.
39 citations
,
April 2010 in “International Journal of Pharmaceutics” This study found that using monoolein cubic phase nanoparticles with an entrapped hydroxypropyl β-cyclodextrin/minoxidil complex increased minoxidil skin permeation, but minoxidil retention in the skin was higher with a traditional solution.
8 citations
,
January 2018 in “PubMed” The study reported that reducing finasteride particle size significantly improved its cellular permeation through prostate epithelial cells, though it had a lesser impact on systemic pharmacokinetics and tissue distribution in rats.
6 citations
,
August 2020 in “Journal of Pharmaceutical Innovation” This study found that a lipid nanoemulsion-based gel of finasteride for topical use improved hair growth and was effective against alopecia, with slow skin permeation and increased efficacy compared to a testosterone-treated group.
4 citations
,
October 2019 in “Journal of Dermatological Treatment” This study reported that injecting monofilament threads into the scalp significantly improved hair count and hair mass index in women with female pattern hair loss, with most participants noticing substantial improvements in hair characteristics compared to a placebo.
August 2025 in “Anais Brasileiros de Dermatologia” This review details phenol's dermatological uses and underscores its potent skin rejuvenation effects but emphasizes the need for caution due to risks of serious complications, including cardiac arrhythmias and organ failure, particularly with improper use or large-area applications.
224 citations
,
March 2006 in “Seminars in Cutaneous Medicine and Surgery” This article discusses the hair follicle's regenerative cycles and the molecular mechanisms influencing them, emphasizing the need for therapeutic targeting of the "hair cycle clock" to manage hair growth disorders, without reporting new research findings.
215 citations
,
September 2003 in “Journal of Biological Chemistry” This study found that the hairless gene product (Hr) suppresses VDR-mediated gene activation by directly interacting with the vitamin D receptor, potentially affecting hair follicle function.
181 citations
,
January 2009 in “Nature Genetics” In this study, researchers linked defects in U2HR, an inhibitory region in the HR gene, to Marie Unna hereditary hypotrichosis, suggesting a mechanism for controlling hair growth and addressing hair loss.
178 citations
,
October 2001 in “Genes & Development” This study found that the mammalian hairless gene encodes a corepressor protein that interacts with thyroid hormone receptors, providing insights into hair loss syndromes in humans and mice.
166 citations
,
July 1999 in “American Journal Of Pathology” This study found that the loss of a functional hr gene in mice leads to premature and abnormal hair follicle regression, disrupting normal hair cycling and architecture.
162 citations
,
August 2002 in “Survey of Ophthalmology” This study found that latanoprost induces significant growth and pigmentation of lashes and ancillary hairs, with effects mirroring both brief and chronic treatments observed in patients and animal models.