Phenol in Dermatology: Updated Evidence on Efficacy and Safety

Phenol is a potent compound used in dermatology for conditions like alopecia areata, vitiligo, and acne scars, and is particularly effective in deep peels for skin rejuvenation due to its ability to promote neocollagenesis. Despite its efficacy, phenol poses significant risks, including cardiac arrhythmias and organ failure, due to its rapid absorption and toxic profile. Historical and recent cases of fatal poisoning underscore the necessity for its cautious use, requiring procedures to be conducted by highly trained physicians with strict monitoring to ensure safety and therapeutic effectiveness.