May 2024 in “Cardiometry” This study documented that after hair transplantation, 34 patients with white or gray hair in the donor area experienced color repigmentation, with most regaining their original blackish color in the recipient area over a 1-year follow-up.
1 citations
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October 2013 in “BMJ” This case study reports a man with rapid hair thinning, whitening, and sparse beard, linked to an increased proportion of hair follicles in catagen or telogen phase and peribulbar lymphocytic infiltrate.
August 2026 in “International Journal of Bioprinting” This review highlights the complexities of hair graying and the limitations of current models to fully replicate hair follicle pigmentary unit function, suggesting that technologies like organoids and bioprinting show promise but require further development for effective hair repigmentation interventions.
14 citations
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April 2016 in “British Journal of Dermatology” This study found that a combined pattern of repigmentation was most commonly observed in vitiligo, with a new 'medium spotted' pattern proposed for areas with few hair follicles.
12 citations
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May 2023 in “EMBO reports” In this study with organ-cultured human scalp hair follicles, high mTORC1 activity correlated with gray/white hair and reduced pigmentation, while inhibiting mTORC1 with rapamycin increased hair growth and pigmentation, suggesting mTORC1 inhibition could be a strategy for treating hair depigmentation and loss.
1 citations
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March 2019 in “Actas Dermo-Sifiliográficas” This review discusses the adverse effects on hair associated with targeted cancer therapies and reports no new clinical results; it emphasizes the need for comprehensive documentation of these effects.
2 citations
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March 2018 in “The Journal of Dermatology” This letter discusses a trichoscopic feature called the color-transition sign for differentiating between alopecia areata incognita and telogen effluvium, and reports no new clinical results.
2 citations
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September 2020 in “International journal of radiology & radiation therapy” This study describes changes in scalp hair color, including rare instances of repigmentation, following volumetric modulated arc therapy for skin cancer; this potential side effect may warrant discussion during informed consent.
January 1990 in “Springer eBooks” Some chemicals can permanently or temporarily remove color from skin and hair, which can be distressing and is not well-regulated in cosmetics.
2 citations
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November 2024 in “JAAD Case Reports” Anti-PD-L1 immunotherapy can cause hair loss and unexpected hair color change, but treatment can restore hair growth and color.
April 2025 in “Turkish Journal of Hematology” Nilotinib may cause gray hair to return to its original color.
June 2025 in “Clinical and Experimental Dermatology” This report describes a rare case where a 76-year-old man's grey scalp hair unexpectedly regained its original orange to brown color after he underwent radiotherapy for squamous cell carcinoma, suggesting possible implications involving hair follicle melanocytes and radiation effects.
In this case study, a patient experienced darkening of hair color after taking acitretin, an oral retinoid known for potentially causing alopecia, marking a rare and undocumented phenomenon.
January 2016 in “Lithuanian University of Health Sciences” This study in a Lithuanian veterinary clinic observed diverse histomorphological skin changes in alopecic dogs caused by various rare diseases, including hyperkeratinization and pigmentation disorders.
April 2024 in “Authorea (Authorea)” This case report describes a patient with chronic renal failure on hemodialysis who experienced hair depigmentation while taking heptaminol, with the condition reversing after discontinuing the medication; the exact mechanism causing the color change is still unclear.
1 citations
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September 2024 in “Journal of Oncology Pharmacy Practice” In this report, a 77-year-old woman treated for essential thrombocytosis with low-dose hydroxyurea experienced an unexpected change in hair color from gray to dark brown after 20 weeks, highlighting a potential aesthetic side effect of the drug, in addition to therapeutic effects.
11 citations
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October 2015 in “Journal der Deutschen Dermatologischen Gesellschaft” This study observed that women post-bariatric surgery may be at increased risk for dermatological signs of malnutrition during subsequent pregnancies, highlighting the need for dermatologists to recognize these early symptoms.
14 citations
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July 1977 in “PubMed” This study reported that a 19-year-old man's essential fatty acid deficiency was reversed with daily topical application of linoleic acid, improving clinical symptoms and normalizing certain fatty acid levels.
3 citations
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June 2025 in “Stem Cell Research & Therapy” Hair follicle-derived melanocyte transplant could effectively treat vitiligo by restoring skin color.
May 2015 in “Journal of the American Academy of Dermatology” New hair after alopecia areata can be thinner and change color but usually keeps the same shape.
8 citations
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August 2018 in “BMJ Case Reports” This case report describes a patient who experienced rapid hair depigmentation after starting pazopanib for metastatic renal cell carcinoma, which may suggest therapy success despite being distressing.
62 citations
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December 1941 in “Experimental biology and medicine” In this study, phenylthiocarbamide intake was associated with hair graying in rats, while switching to tap water led some rats to regain their original fur color, suggesting dietary factors influence pigmentation.
3 citations
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May 2010 in “Archives of dermatology” This excerpt discusses website navigation and access details for JAMA Dermatology and reports no new research findings.
25 citations
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March 2012 in “Journal of oncology pharmacy practice” This case report describes an elderly multiple myeloma patient whose hair repigmentation was associated with lenalidomide use, suggesting hair graying may be reversible.
17 citations
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January 2015 in “Dermatology online journal” This report describes a patient experiencing hair repigmentation linked to adalimumab therapy, a TNF inhibitor, a phenomenon not previously associated with this class of drugs.
9 citations
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July 2016 in “The Journal of Dermatology” This letter to the editor discusses an observed case of hair repigmentation linked with etretinate therapy but reports no new research findings.
1 citations
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November 2021 in “Oman Medical Journal” In this report, a 65-year-old Omani male undergoing cyclosporine A treatment experienced hair repigmentation as a rare side effect.
1 citations
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December 2013 in “Balkan Journal of Medical Genetics” This case study describes a 3.5-month-old girl with cystic fibrosis who experienced hair and skin depigmentation, which resolved after treatment with pancreatic enzymes and vitamins.
October 2007 in “Journal of Investigative Dermatology” The document suggests a bacteria plays a significant role in acne rosacea and that white hair can regain color after transplant, meriting more research on reversing grey hair.
69 citations
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April 1998 in “Journal of The American Academy of Dermatology” In this study, single hair grafting was reported to be an effective treatment for localized/segmental vitiligo, notably in hairy skin areas, with repigmentation observed in 82% of those cases.