Graying of Hair Produced by Ingestion of Phenylthiocarbamide
December 1941
in “
Experimental biology and medicine
”
Studysummary In this study, phenylthiocarbamide intake was associated with hair graying in rats, while switching to tap water led some rats to regain their original fur color, suggesting dietary factors influence pigmentation.
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The document discusses the effects of phenylthiocarbamide (PTC) on hair graying, highlighting its role as an antithyroid drug. It includes various studies on the toxicological aspects of melanin and melanogenesis, chemically induced depigmentation, and the impact of PTC on pigmentation in different species, such as zebrafish and Xenopus laevis. The research also explores the broader physiological and endocrinological effects of antithyroid agents, including their influence on thyroid metabolism and hormonal states affecting hair growth. The findings suggest that PTC and similar compounds can significantly alter pigmentation and thyroid function, leading to observable changes like hair graying.
