research In Search of New Therapeutics: Molecular Aspects of the PCOS Pathophysiology - Genetics, Hormones, Metabolism and Beyond
New treatments are needed for PCOS that target its genetic, hormonal, and metabolic causes.
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210-240 / 772 resultsresearch Physiology of Testicular Function
The testes produce sperm and hormones essential for male development.
research New Treatments of Hyperandrogenism and Hirsutism
Hirsutism causes significant psychological distress in women.
research Effect of a Six-Month Treatment Regimen of Metformin on 17-Hydroxyprogesterone Responses to GnRH Agonist in Polycystic Ovary Syndrome
Metformin can start ovulation and may lower 17P response in PCOS, but six months is too short to improve hair growth or change body fat distribution.
research An Open Randomized Comparative Study of an Oral Contraceptive Containing Ethinyl Estradiol and Cyproterone Acetate with and without the GnRH Analogue Goserelin in the Long-Term Treatment of Hirsutism
The oral contraceptive alone is the preferred treatment for hirsutism, as adding the GnRH analog showed no significant benefit.
research Three-Month Treatment With a Long-Acting Gonadotropin-Releasing Hormone Agonist of Patients With Benign Prostatic Hyperplasia: Effects on Tissue Androgen Concentration, 5α-Reductase Activity and Androgen Receptor Content
A three-month treatment with a GnRH agonist significantly lowered androgen levels and 5α-reductase activity in men with benign prostatic hyperplasia.
research 17-Hydroxyprogesterone Responses to Gonadotropin-Releasing Hormone Reveal Distinct Phenotypes of Functional Ovarian Hyperandrogenism and Polycystic Ovary Syndrome
The research found that polycystic ovary syndrome (PCOS) has two distinct types, with one having more severe hormone and insulin issues.
research Gonadotropin-Releasing Hormone Agonist Treatment in Postmenopausal Women with Hyperandrogenism of Ovarian Origin
Treatment with a hormone agonist can reduce excess male hormones in postmenopausal women without surgery.
research A Systematic Review of Antiandrogens and Feminization in Transgender Women
Some antiandrogens may lower testosterone better than others, but it's unclear which is best for feminization in transgender women; more research is needed.
research The Hyperandrogenic-Insulin-Resistant Acanthosis Nigricans Syndrome: Therapeutic Response
Most patients improved with oral contraceptives, but some needed additional treatment.
research Treatment of Hirsutism with a Gonadotropin-Releasing Hormone Agonist and Estrogen Replacement Therapy
The combination therapy reduced hirsutism in women with PCOD and was well-tolerated.
research Postmenopausal Ovarian Hyperthecosis Associated with Rapid Testosterone Excess
Removing both ovaries can treat increased testosterone and related symptoms in postmenopausal women with ovarian hyperthecosis.
research Ovarian Hyperthecosis in Adolescent Females: Two Case Reports and a Review of the Literature
Ovarian hyperthecosis should be considered in young women with severe male-like symptoms and can be managed with hormone treatments.
research Comparative Management Methods for Adolescents With Polycystic Ovarian Syndrome: A Systematic Review
Individualized treatment plans, including lifestyle changes and specific medications, are crucial for managing PCOS in adolescents.
research A Rare Cause of Hyperandrogenism in Postmenopausal Women: Ovarian Stromal Hyperplasia
Ovarian stromal hyperplasia can cause high testosterone in postmenopausal women and is treated by removing the ovaries.
research Treatment of Hirsutism with a Gonadotropin-Releasing Hormone Agonist (Nafarelin)
Nafarelin may effectively treat excessive hair growth in women by reducing certain hormone levels.
research Management of Hirsutism
Antiandrogens, particularly flutamide and CPA, are most effective for treating hirsutism, with long-term use needed for best results.
research Gonadotrophin-Releasing Hormone Agonist Therapy for Hirsutism Is as Effective as High Dose Cyproterone Acetate but Results in a Longer Remission
Hormone therapy for excessive hair growth is as good with GnRHa as with high-dose CPA, but GnRHa has longer-lasting results.
research Interventions for Hirsutism (Excluding Laser and Photoepilation Therapy Alone)
Some medicines can reduce excessive hair growth in women, but more research is needed to compare treatments and consider side effects.
research Interventions for Hirsutism Excluding Laser and Photoepilation Therapy Alone: Abridged Cochrane Systematic Review Including GRADE Assessments
Some medications can reduce excessive hair growth in women, but more research is needed to find the best treatment combinations.
research Hormonal Therapies for Acne
Hormonal treatments can improve acne, but they come with potential side effects and risks.
research Effect of the Gonadotrophin-Releasing Hormone Analogue, Goserelin, and Estradiol Replacement on Sebum Excretion Rates and Hair Size in Mildly Hirsute Women
Goserelin and oestradiol treatment slightly improved hairiness but did not significantly change sebum production or hair characteristics in mildly hirsute women.
research Hirsutism And Hypertrichosis In Adults: Investigations And Treatment
The document concludes that treatment for excessive hair growth depends on the cause, with options including hair removal methods and medications like anti-androgens or insulin-sensitizing drugs.
research A Case of Ovarian Hyperthecosis in a Postmenopausal Woman
A postmenopausal woman's excess male hormone symptoms improved after her ovaries were removed.
research Triple Hormonal Blockade (ADT3): A Patient’s Perspective
Triple Hormonal Blockade (ADT3) can effectively manage prostate cancer but requires careful monitoring for heart risks.
research Reporting on Adverse Clinical Events
Monitoring for adverse effects in clinical treatments is crucial.
research Adult Onset Isolated Hypogonadotropic Hypogonadism: A Cause of Secondary Amenorrhea
A 23-year-old woman's missed periods were caused by a rare genetic disorder treated with hormone patches.
research Neural Substrates of the Emotional Negativity Bias as Revealed by Hemodynamic Data
Cyproterone acetate is a safe treatment that causes mild feminizing effects in adolescent trans-girls.
research Slow Progress in Prostate Cancer
Finasteride reduces prostate cancer risk but may increase high-grade tumors; new drugs and better diagnosis are in development, but funding and industry commitment are challenges.
research Polycystic Ovary Syndrome (PCOS): French Endocrine Society Recommendations for Diagnosis and Management
The French Endocrine Society suggests diagnosing PCOS with two of three signs, recommends lifestyle changes and clomiphene for treatment, and calls for more research on certain treatments and tests.