Reporting on Adverse Clinical Events

November 2010 in “ Clin-Alert ”

estrogen therapy fluoxetine serotonin toxicity olanzapine gonadotropin-releasing hormone agonists estrogen Prozac GnRH agonists

TLDR Monitoring for adverse effects in clinical treatments is crucial.

The document reported on various adverse clinical events associated with different medications. Key findings included an increased risk of nephrolithiasis in 27,347 postmenopausal women on estrogen therapy, no significant symptom reduction in 324 male patients with chronic prostatitis using pregabalin, and several case reports of adverse reactions such as suicidal ideations from fluoxetine, serotonin toxicity from olanzapine, and posterior reversible encephalopathy following a measles vaccination. The FDA also issued safety alerts against unapproved chelation agents and highlighted risks of diabetes and cardiovascular diseases with gonadotropin-releasing hormone agonists. The authors concluded that these findings underscore the importance of monitoring for adverse effects in clinical treatments.

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community High Estrogen causing hair loss?

in Treatment 15 upvotes 1 year ago

A 24-year-old male using topical finasteride for hair loss is experiencing thinning despite treatment and has high estrogen levels. He is seeking advice on whether high estrogen could be causing hair loss and how others with high estrogen levels have addressed it.

community Trying to understand finasteride side effects and post finasteride syndrome

in Finasteride/Dutasteride 73 upvotes 4 years ago

The conversation discusses the side effects of finasteride, including low libido and erectile dysfunction, and the possibility of these effects being permanent, known as post-finasteride syndrome (PFS). Some users report personal experiences with PFS and debate whether the condition is real, with varying opinions on the reversibility of side effects and the role of individual biology.

community 3 months progress with Finasteride 0.5mg/daily, Minoxidil foam5% 2x daily, Stemoxydine 2x daily, Microneedling(M8) 1.5mm 1x per week, Saw Palmetto 400mg/day, peppermint and jojoba oils daily, Ketoconazole 2% shampoo 3x/week, Purador shampoo/conditioner every day.

in Progress Pictures 337 upvotes 2 years ago

Jordan-Iliad has been using a combination of finasteride, minoxidil, stemoxydine, microneedling, saw palmetto, peppermint and jojoba oils, ketoconazole shampoo, and Purador shampoo/conditioner for 3 months to treat their hair loss with stunning results. They have also recently started taking oral minoxidil 1.25mg/day in hopes of achieving even better results over the next 3 months.

community Estrogen is an anabolic for scalp hair, if you mix it with growth stimulants such as oral minoxidil. All we need is an artificial SARM-estrogen that will work only with hair and will be invisible for the rest of the body + some next level AA only for hair – goodbye hair transplant industry

in Transgender 137 upvotes 3 years ago

Hair loss discussion mentions using estrogen mixed with growth stimulants like oral minoxidil for scalp hair growth. Idea proposed for an artificial SARM-estrogen that only affects hair without body side effects.

community Spironolactone, what do you think?

in Finasteride/Dutasteride 4 upvotes 4 months ago

A user is considering Spironolactone for hair loss but is advised against it due to its effects on testosterone. Instead, they are recommended to try finasteride at 18 and consider dutasteride if needed.

community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

in Female 53 upvotes 1 year ago

A 30-year-old female with PCOS and male pattern baldness is frustrated with her endocrinologist's recommendation of only Spironolactone and minoxidil, feeling that dutasteride, finasteride, and progesterone would be more effective. Other users suggest various online sources for treatments, warn against self-medicating due to potential risks, and recommend seeking a specialized endocrinologist or considering additional treatments like Inositol, Berberine, and dermaneedling.

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