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Tacrolimus causes fewer acute rejections than cyclosporin A in kidney transplants but doesn't necessarily improve kidney function after one year; cardiovascular risks and side effects vary between the two drugs.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

The document concludes that the understanding of scar formation is incomplete and current prevention and treatment for hypertrophic scars and keloids are not fully effective.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Understanding hair growth involves complex interactions between molecules and could help treat hair disorders.

Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Modern lifestyles, including poor diet, stress, and long-term use of certain medications, hinder the body's ability to heal from inflammation, leading to chronic diseases.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

PPAR agonists show promise for skin conditions but need more research before being a main treatment.

Testosterone may slow down wound healing and increase inflammation.

Dupilumab is being tested for many new skin, respiratory, and gastrointestinal conditions.

Androgens prevent hair growth by changing Wnt signals in cells.

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

Eclipta prostrata has many traditional uses and health benefits, but more research is needed to understand how it works and ensure it's safe.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.

Transit-amplifying cells are crucial for tissue repair and can contribute to cancer when they malfunction.

The document concludes that ongoing research using animal models is crucial for better understanding and treating Alopecia Areata.

DHT stops hair regrowth in mice, similar to human hair loss.

Cholesterol-related compounds can stop hair growth and cause inflammation in a type of scarring hair loss.

Long-term use of dutasteride for enlarged prostate may worsen blood sugar, cholesterol, and erectile dysfunction.

New treatments for hair loss may target specific pathways and generate new hair follicles.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

SARS-CoV-2, the virus causing COVID-19, can affect all endocrine organs and systems, altering their function and potentially leading to disorders. Factors like diabetes and obesity increase infection risk and severity. Understanding these effects is key for effective treatment.

Different types of fibroblasts play various roles in kidney repair and aging, and may affect chronic kidney disease outcomes.

Selective breeding caused the unique curly hair in Mangalitza pigs.

Pig skin cells can turn into mesodermal cells but lose their ability to become neural cells.

Different substances that activate or block the androgen receptor can affect male development and treat conditions like prostate cancer.

Fat tissue stem cells show promise for repairing different body tissues and are being tested in clinical trials.