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Prolactin contributes to hair loss by promoting hair follicle shrinkage and cell death.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

People with PCOS, especially if obese, often have NAFLD, linked to obesity, insulin resistance, and high androgen levels.

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

Hormones and metabolism play a complex role in prostate enlargement, and more research is needed to improve diagnosis and treatment.

Mutations in the PADI3 gene are linked to a higher risk of scarring hair loss in women of African descent.

The document concludes that hirsutism is the main sign for diagnosing hyperandrogenism, which requires a detailed patient history and physical exam.

Lichen Planopilaris and Frontal Fibrosing Alopecia may help us understand hair follicle stem cell disorders and suggest new treatments.

PCOS in teens is hard to diagnose, linked to genetics and lifestyle, and managed with weight loss and medication.

Short-chain fatty acids from *Cutibacterium acnes* cause skin inflammation, contributing to acne.

Skin problems are very common in people with end-stage kidney disease.

An imbalance between certain immune cells is linked to a chronic skin condition and may be influenced by obesity, smoking, and autoimmune issues.

Blocking the CXCR3 receptor reduces T cell accumulation in the skin and prevents hair loss in mice.

Polycystic Ovary Syndrome is linked to higher risk of hypertension and heart disease.

Insulin resistance contributes to hormone imbalances in many women with polycystic ovary syndrome.

There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.

The conclusion is that individual differences in COVID-19 severity are influenced by factors like age, sex, race, and genetics, which are important for personalized medicine.

Oral retinoids are effective for severe skin conditions but require careful use due to side effects.

The conclusion is that acne, alopecia, and hyperhidrosis are common skin issues with various treatments available, and accurate diagnosis is key for effective management.

Polycystic Ovary Syndrome is common but often undiagnosed, and early treatment is important to prevent health problems.

Men are more likely to get infectious skin diseases, while women are more prone to autoimmune and pigment-related skin conditions, influenced by biological and environmental factors.

Mice lacking Insig proteins had hair growth problems due to cholesterol buildup, but this was fixed by the drug simvastatin.

Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.

Lifestyle changes are the main treatment for PCOS, which is a complex condition requiring early management to reduce its health impacts.

Some patients with mycosis fungoides or Sézary syndrome experience hair loss, which may be similar to alopecia areata or linked to skin lesions, possibly due to abnormal T cells, and bexarotene can help treat it.

SCF and c-Kit decrease in AGA hair follicles, possibly affecting hair pigmentation and growth.

The hair follicle infundibulum plays a key role in skin health and disease, and understanding it better could lead to new skin disease treatments.

Adrenal disorders can cause lasting brain and behavior issues in children.