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    Glossary GABAA Receptors

    ion channels in the brain that reduce neuronal excitability

    GABAA receptors, also known as Gamma-Aminobutyric Acid Type A receptors, are a class of receptors in the brain that respond to the neurotransmitter GABA, the primary inhibitory neurotransmitter in the central nervous system. These receptors are ion channels that, when activated, allow chloride ions to enter the neuron, making it less likely to fire and thus reducing neuronal excitability. This mechanism is crucial for regulating brain activity and is a target for various medications, including sedatives, anxiolytics, and anticonvulsants.

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    Research 30 of 524

    1. PR-independent neurosteroid regulation of α2-GABA-A receptors in the hippocampus subfields Brain research · 2017 · 14 citations
    2. Effect of Neurosteroid Withdrawal on Hippocampal GABA‐A Receptor α4‐Subunit Expression in Female Mice The FASEB Journal · 2008
    3. Ovarian Cycle‐Related Neurosteroid Regulation of GABA‐A Receptor Subunit Plasticity in the Hippocampus Subfields The FASEB Journal · 2011 · 1 citations
    4. Catamenial-like seizure exacerbation in mice with targeted ablation of extrasynaptic δGABA-a receptors in the brain Journal of neuroscience research · 2017 · 12 citations
    5. Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor Neurobiology of Stress · 2019 · 40 citations
    6. Aqueous extract of Asiasari radix inhibits formalin-induced hyperalgesia via NMDA receptors Journal of Ethnopharmacology · 2009 · 17 citations
    7. Allopregnanolone is required for prepulse inhibition deficits induced by D1 dopamine receptor activation Psychoneuroendocrinology · 2019 · 12 citations
    8. Social isolation alters GABAA receptors plasticity and function: effect of voluntary consumption of ethanol Annals of General Psychiatry · 2008
    9. Joint Public Review: Touch receptor end-organ innervation and function require sensory neuron expression of the transcription factor Meis2 2024
    10. Changes in expression of the δ subunit of the GABA<sub>A</sub>receptor and in receptor function induced by progesterone exposure and withdrawal Journal of Neurochemistry · 2006 · 25 citations
    11. Effects of Subchronic Finasteride Treatment and Withdrawal on Neuroactive Steroid Levels and Their Receptors in the Male Rat Brain Neuroendocrinology · 2015 · 33 citations
    12. Neurosteroid Synthesis-Mediated Regulation of GABA<sub>A</sub>Receptors: Relevance to the Ovarian Cycle and Stress Journal of Neuroscience · 2007 · 238 citations
    13. Production of 5α-Reduced Neurosteroids Is Developmentally Regulated and Shapes GABA<sub>A</sub>Miniature IPSCs in Lamina II of the Spinal Cord Journal of Neuroscience · 2004 · 88 citations
    14. Neurosteroids, neuroactive steroids, and symptoms of affective disorders Pharmacology, Biochemistry and Behavior · 2006 · 82 citations
    15. Progesterone, neurosteroids, and the hormonal basis of catamenial epilepsy Annals of Neurology · 2003 · 30 citations
    16. The neurosteroid environment in the hippocampus exerts bi-directional effects on seizure susceptibility in mice Brain Research · 2008 · 21 citations
    17. Relating neurosteroid modulation of inhibitory neurotransmission to behaviour Journal of Neuroendocrinology · 2021 · 18 citations
    18. Brain allopregnanolone induces marked scratching behaviour in diet-induced atopic dermatitis mouse model Scientific reports · 2019 · 6 citations
    19. Synthesis and Actions of 5α-Reduced Metabolites of Testosterone in the Nervous System Androgens · 2021 · 1 citations
    20. Lactium: A Novel Drug for Psychocutaneous Skin Disorders Journal of skin and stem cell · 2021
    21. Mitochondrial dysfunction in diabetic neuropathy may be involved in the development of neuropathic pain via a reduction in neurosteroid synthesis F1000Research · 2017 · 4 citations
    22. Neurosteroids as Endogenous Regulators of Seizure Susceptibility 2002
    23. Social isolation‐induced increase in α<sub>4</sub>and δ subunit gene expression is associated with a greater efficacy of ethanol on steroidogenesis and GABA<sub>A</sub>receptor function Journal of Neurochemistry · 2006 · 60 citations
    24. Progesterone and allopregnanolone enhance the miniature synaptic release of glycine in the rat hypoglossal nucleus European Journal of Neuroscience · 2009 · 28 citations
    25. Roles of Type 10 17beta-Hydroxysteroid Dehydrogenase in Intracrinology and Metabolism of Isoleucine and Fatty Acids Endocrine, metabolic & immune disorders. Drug targets · 2006 · 26 citations
    26. Implications of neuroimaging for the treatment of epilepsy Annals of Neurology · 2003 · 2 citations
    27. Neuroactive Steroids: Functions, Mechanisms of Action and Physiologic Relevance Journal of Neurochemistry · 2003
    28. Stress-Induced Deoxycorticosterone-Derived Neurosteroids Modulate GABA<sub>A</sub>Receptor Function and Seizure Susceptibility Journal of Neuroscience · 2002 · 269 citations
    29. Antidepressant-like effect of fluoxetine may depend on translocator protein activity and pretest session duration in forced swimming test in mice Behavioural Pharmacology · 2017 · 7 citations
    30. Neurosteroidogenesis Is Required for the Physiological Response to Stress: Role of Neurosteroid-Sensitive GABA<sub>A</sub>Receptors Journal of Neuroscience · 2011 · 248 citations